INT270802

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 41.92 Quite Low
cytokine 9 34.88 Quite Low
Inflammation 10 34.52 Quite Low
antagonist 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 41.60 Quite Low
Disease 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this hypothesis cannot yet be ruled out in the specific case of P2X7R function, it quickly became apparent that this cannot be a general mechanism by which panx1 signals to inflammasome activation when it was found that panx1 inhibition (via CBX, panx1 gene silencing, and 10panx1 inhibitory peptide) also inhibits processing and release of bioactive IL-1?
Negative_regulation (inhibitory) of Gene_expression (peptide) of 10panx1
1) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0

General Comments

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