INT270805

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 6 21.76 Low Low
cytokine 27 14.72 Low Low
Inflammation 30 14.36 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 76.00 Quite High
INFLAMMATION 36 21.44 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High concentrations of extracellular ATP activates P2X7R ion channel resulting in a cation permeability (Na+ influx/K+ efflux and intracellular Ca++ rise) and the activation of panx1.
Positive_regulation (activates) of Positive_regulation (activation) of panx1
1) Confidence 0.45 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0
release induced by P2X7R and panx1 activation.
Positive_regulation (induced) of Positive_regulation (activation) of panx1
2) Confidence 0.45 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
as well as enhances the expression and activity of P2X7R and panx1.
Positive_regulation (enhances) of Positive_regulation (activity) of panx1
3) Confidence 0.42 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.05 Pain Relevance 0

General Comments

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