INT270806

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.30
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Anatomy Link Frequency
pore 1
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 14 84.56 Quite High
cytokine 63 49.68 Quite Low
Inflammation 70 13.52 Low Low
antagonist 21 5.00 Very Low Very Low Very Low
addiction 14 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
Neuropathic pain 7 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Potency 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 88.72 High High
INFLAMMATION 84 84.20 Quite High
Disease 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High concentrations of extracellular ATP activates P2X7R ion channel resulting in a cation permeability (Na+ influx/K+ efflux and intracellular Ca++ rise) and the activation of panx1.
Positive_regulation (activation) of panx1
1) Confidence 0.62 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0
release induced by P2X7R and panx1 activation.
Positive_regulation (activation) of panx1
2) Confidence 0.62 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
We recently identified pannexin-1 (panx1) as a P2X7R-associated protein which appears to be the large pore or is responsible for activation of the large pore [40].
Positive_regulation (activation) of panx1 in pore
3) Confidence 0.45 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
This novel hypothesis is based on observations that cytosolic delivery of the bacterial PAMP lysosomic muramyl dipeptide (MDP) activated the inflammasome in a manner similar to P2X7R and that P2X7R activation induced a panx1-dependent lysosome-to-cytosol translocation of MDP [61, 62].
Positive_regulation (induced) of panx1-dependent
4) Confidence 0.45 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0.04
Panx1 activation allows a rapid dye uptake permeabilization pathway and potentially the entry of either bacterial PAMPs and/or extracellular ATP that will directly activate NLRP3 (nucleotide-binding domain and leucine-rich repeat containing a pyrin domain) molecule using the adaptor molecule ASC (apoptosis-associated speck-like protein containing a CARD).
Positive_regulation (activation) of Panx1 associated with apoptosis
5) Confidence 0.42 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0
as well as enhances the expression and activity of P2X7R and panx1.
Positive_regulation (activity) of panx1
6) Confidence 0.42 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.05 Pain Relevance 0
Initially, panx1 was expected to be a conduit for the high K+ efflux subsequent to P2X7R activation, but inhibition of panx1 using 10panx1 inhibitory peptide abolished caspase-1 activation without altering P2X7R-mediated K+ efflux [40].
Positive_regulation (activation) of 10panx1
7) Confidence 0.39 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0

General Comments

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