INT270810

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.33
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Anatomy Link Frequency
macrophage 2
erythrocytes 1
pore 1
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 12 91.48 High High
cytokine 54 84.44 Quite High
Inflammation 60 84.08 Quite High
addiction 12 63.00 Quite High
antagonist 18 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 72 91.16 High High
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence has been presented to suggest panx1 can act as a conduit for ATP release from erythrocytes [64].
Localization (release) of panx1 in erythrocytes
1) Confidence 0.67 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0.03
Firstly, it is not clear how a P2X7R/panx1 permeabilization pore that is presumably limited to molecules <900 Da can transfer larger PAMPs.
Localization (permeabilization) of panx1 in pore
2) Confidence 0.67 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.07 Pain Relevance 0.07
Panx1 and P2X7R co-immunoprecipitated in HEK 293 cells; small interfering RNA (siRNA) directed against panx1, a panx1-mimetic inhibitory peptide (10panx1 peptide), and CBX all inhibited P2X7R-mediated dye uptake but not membrane currents or calcium flux in HEK 293 cells and in human and murine macrophage [40].
Localization (immunoprecipitated) of Panx1 in macrophage
3) Confidence 0.67 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
This novel hypothesis is based on observations that cytosolic delivery of the bacterial PAMP lysosomic muramyl dipeptide (MDP) activated the inflammasome in a manner similar to P2X7R and that P2X7R activation induced a panx1-dependent lysosome-to-cytosol translocation of MDP [61, 62].
Localization (translocation) of panx1-dependent
4) Confidence 0.63 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0.07
There are currently no studies showing high-resolution subcellular localization of endogenous panx1 in macrophage using antibodies that are highly specific for panx1. (5) Can endogenous panx1-like currents be recorded from macrophage?
Localization (localization) of panx1 in macrophage
5) Confidence 0.62 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0.03
, as well as P2X7R and panx1 [40, 52–55], but a secondary stimulus is required for efficient processing and release of bioactive IL-1?
Localization ([40) of panx1
6) Confidence 0.58 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.18 Pain Relevance 0.13

General Comments

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