INT270811

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 0.40
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Anatomy Link Frequency
plasma 1
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 108 80.64 Quite High
Inflammation 120 80.28 Quite High
Inflammatory stimuli 24 69.48 Quite High
addiction 24 20.96 Low Low
Potency 12 10.88 Low Low
antagonist 36 5.00 Very Low Very Low Very Low
agonist 24 5.00 Very Low Very Low Very Low
Neuropathic pain 12 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 144 80.28 Quite High
Toxicity 12 52.64 Quite High
Apoptosis 12 47.72 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of panx1 not only inhibited caspase-1-dependent processing and release of both IL-1?
Negative_regulation (inhibition) of panx1
1) Confidence 0.52 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.13 Pain Relevance 0.08
and maitotoxin evokes only a panx1-independent slow onset of dye uptake, but in both cases, panx1 inhibition prevents IL-1?
Negative_regulation (inhibition) of panx1
2) Confidence 0.52 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Initially, panx1 was expected to be a conduit for the high K+ efflux subsequent to P2X7R activation, but inhibition of panx1 using 10panx1 inhibitory peptide abolished caspase-1 activation without altering P2X7R-mediated K+ efflux [40].
Negative_regulation (inhibition) of panx1
3) Confidence 0.52 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
However, panx1 inhibition does not alter membrane currents or calcium influx in response to P2X7R activation (see above).
Negative_regulation (inhibition) of panx1
4) Confidence 0.52 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Notably, inhibition of panx1 blocked only an initial phase of the P2X7R-induced dye uptake, revealing a previously undetected slow (panx1-independent) dye uptake (Fig. 2) [42].
Negative_regulation (inhibition) of panx1
5) Confidence 0.52 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
While this hypothesis cannot yet be ruled out in the specific case of P2X7R function, it quickly became apparent that this cannot be a general mechanism by which panx1 signals to inflammasome activation when it was found that panx1 inhibition (via CBX, panx1 gene silencing, and 10panx1 inhibitory peptide) also inhibits processing and release of bioactive IL-1?
Negative_regulation (inhibition) of panx1
6) Confidence 0.38 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Fig. 2Two phases to P2X7R-mediated dye uptake revealed by inhibition of panx1. a Original traces of typical dye uptake experiments carried out on HEK 293 cells expressing rat P2X7R; each trace shows average ± SEM from 20 to 30 cells; control fluorescence (in arbitrary fluorescence units) saturates the optical system in both examples.
Negative_regulation (inhibition) of panx1
7) Confidence 0.38 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Panx1 cartoon is represented as a plasma membrane hemichannel consisting of a complex of six subunits, hypothetically arranged based on analogy to connexin gap junction hemichannels
Negative_regulation (represented) of Panx1 in plasma
8) Confidence 0.38 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
CBX, siRNA gene silencing of panx1 protein, and 10panx1 inhibitory peptide all inhibit P2X7R-mediated IL-1?
Negative_regulation (silencing) of panx1 protein
9) Confidence 0.38 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.13 Pain Relevance 0.10
Inhibition of panx1 with CBX or 10panx1-mimetic inhibitory peptide dramatically delays dye uptake; results detailed in [40, 42] suggest two independent processes. b Distinct roles and underlying mechanisms for the two dye uptake processes after P2X7R activation.
Negative_regulation (Inhibition) of panx1
10) Confidence 0.34 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
It is also possible that the panx1 inhibitory peptide may block downstream panx1 signaling without altering direct K+ permeability through panx1 channels.
Spec (may) Negative_regulation (block) of panx1
11) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
CBX, siRNA gene silencing of panx1 protein, and 10panx1 inhibitory peptide all inhibit P2X7R-mediated IL-1?
Negative_regulation (silencing) of 10panx1
12) Confidence 0.15 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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