INT270829

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7, Panx1) protein complex (P2rx7, Panx1) plasma membrane (P2rx7, Panx1)
cell morphogenesis (P2rx7) endoplasmic reticulum (Panx1) mitochondrion organization (P2rx7)
P2rx7 (Mus musculus)
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 4 76.88 Quite High
cytokine 18 75.32 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 76.88 Quite High
Disease 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If K+ efflux is not the link between panx1 and inflammasome activation, an alternative hypothesis comes from the group of Nuñez who have suggested that panx1 activation by P2X7R may act to deliver PAMPs directly into the cytosol where they can then directly bind to leucine-rich repeats present in Nod-like receptors (i.e., NLRP3) to directly activate the inflammasome [61, 62].
P2X7R Positive_regulation (activation) of panx1
1) Confidence 0.66 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.08 Pain Relevance 0.04
A third hypothesis regarding panx1-mediated activation of the inflammasome is that extracellular ATP activates the P2X7R, which in turn activates panx1 hemichannel (or transporter) activity to directly transport ATP into the cell.
P2X7R Positive_regulation (activates) of panx1
2) Confidence 0.44 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0.04

General Comments

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