INT270937

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) aging (Slc6a3)
Golgi apparatus (Cpe) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Cpe (Rattus norvegicus)
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 124 92.80 High High
Kinase C 60 87.44 High High
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Ventral tegmentum 4 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggested that CPE modulated DAT via a posttranslational mechanism, which possibly included reduced degradation of surface DAT.
CPE Regulation (modulated) of DAT
1) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
To explore this possibility, we first tested whether CPE had any effect on the phosphrylation levels of DAT.
CPE Spec (whether) Regulation (effect) of DAT
2) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.16
Here, we have identified that carboxypeptidase E (CPE), a prohormone processing exopeptidase and sorting receptor for the regulated secretory pathway, interacts with the DAT-CT and affects DAT function.
CPE Regulation (affects) of DAT
3) Confidence 0.16 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17
Here, we have identified that carboxypeptidase E (CPE), a prohormone processing exopeptidase and sorting receptor for the regulated secretory pathway, interacts with the DAT-CT and affects DAT function.
carboxypeptidase E Regulation (affects) of DAT
4) Confidence 0.16 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17

General Comments

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