INT27096

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 4
Speculated 10
Reported most in Abstract
Documents 325
Total Number 335
Disease Relevance 195.11
Pain Relevance 109.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
lung 13
macrophages 12
neutrophil 9
nucleus 6
spinal 6
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2384 100.00 Very High Very High Very High
Inflammatory response 198 100.00 Very High Very High Very High
aspirin 164 100.00 Very High Very High Very High
Inflammatory mediators 119 100.00 Very High Very High Very High
Nerve growth factor 52 100.00 Very High Very High Very High
Spinal cord 45 100.00 Very High Very High Very High
alcohol 105 99.98 Very High Very High Very High
Opioid 49 99.98 Very High Very High Very High
Angina 32 99.98 Very High Very High Very High
cytokine 1027 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2628 100.00 Very High Very High Very High
Cancer 863 100.00 Very High Very High Very High
Stress 652 100.00 Very High Very High Very High
Targeted Disruption 351 100.00 Very High Very High Very High
Myocardial Infarction 103 100.00 Very High Very High Very High
Shock 67 100.00 Very High Very High Very High
Hemophilus Infection 623 99.98 Very High Very High Very High
Cv General 3 Under Development 44 99.98 Very High Very High Very High
Pneumonia 100 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 69 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TFLs of 100 Hz EA showed similar trends: a 72.6% increase of TFLs in wild-type, a 38.6% increase in NF-kappaB1+/- and a 9.3% increase in NF-kappaB1-/- mice.
Positive_regulation (increase) of NF-kappaB1 associated with electroacupuncture
1) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11834313 Disease Relevance 0.16 Pain Relevance 0.63
The TFLs of 100 Hz EA showed similar trends: a 72.6% increase of TFLs in wild-type, a 38.6% increase in NF-kappaB1+/- and a 9.3% increase in NF-kappaB1-/- mice.
Positive_regulation (increase) of NF-kappaB1 associated with electroacupuncture
2) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11834313 Disease Relevance 0.16 Pain Relevance 0.62
The participation to persistent pain might rely on activation of NF-kappaB by inflammatory stimuli while the contribution to acute pain responses might be related to constitutive NF-kappaB activity in neurons of the nociceptive system.
Spec (might) Positive_regulation (activation) of NF-kappaB in neurons associated with nociception, pain, acute pain, lasting pain and inflammatory stimuli
3) Confidence 0.70 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17217946 Disease Relevance 1.31 Pain Relevance 0.77
BACKGROUND: NF kappa B (NF-kappaB) is a ubiquitous transcription factor activated by various stimuli implicated in heart failure progression including reactive oxygen species (ROS), hypoxia, and inflammatory cytokines.
Positive_regulation (activated) of NF-kappaB in heart associated with inflammation, hypoxia, myocardial infarction and cytokine
4) Confidence 0.70 Published 2006 Journal FASEB J. Section Abstract Doc Link 16837548 Disease Relevance 0.85 Pain Relevance 0.27
By contrast, islets retain their immunoprotective status and activate nuclear factor-kappaB (NF-kappaB)-induced anti-apoptotic factors, thus enabling survival.
Positive_regulation (activate) of nuclear factor-kappaB associated with apoptosis
5) Confidence 0.69 Published 2006 Journal Trends Mol Med Section Abstract Doc Link 16828345 Disease Relevance 0.67 Pain Relevance 0.19
Cardiac activation of nuclear factor kappa B (NFkappaB) was measured using a NFkappaB luciferase firefly reporter mouse.
Positive_regulation (activation) of NFkappaB
6) Confidence 0.69 Published 2005 Journal Lab. Anim. Section Abstract Doc Link 16004689 Disease Relevance 0.17 Pain Relevance 0.21
In the heart, NF-kappaB has been shown to be activated in atherosclerosis, myocarditis, in association with angina, during transplant rejection, after ischemia/reperfusion, in congestive heart failure, dilated cardiomyopathy, after ischemic and pharmacological preconditioning, heat shock, burn trauma, and in hypertrophy of isolated cardiomyocytes.
Positive_regulation (activated) of NF-kappaB in cardiomyocytes associated with hypertrophy, heart rate under development, angina, ischemia, shock, increased venous pressure under development, graft vs host disease, burns, injury, dilated cardiomyopathy and coronary heart disease
7) Confidence 0.68 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.54 Pain Relevance 0.23
Many of these signaling cascades activate NF-kappaB by activating the IkappaB kinase (IKK) complex a major component of the canonical pathway.
Positive_regulation (activating) of IkappaB
8) Confidence 0.68 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.37 Pain Relevance 0.20
Of the compounds that are known to be NF-kappaB antagonists, the most practical for current use may be the nonsteroidal anti-inflammatory drugs aspirin, salicylic acid, and sulindac, each of which binds to and inhibits Ikappa kinase- beta, a central mediator of NF-kappa activation; the low millimolar plasma concentrations of salicylate required for effective inhibition of this kinase in vivo can be achieved with high-dose regimens traditionally used to manage rheumatic disorders.
Positive_regulation (activation) of NF-kappa in plasma associated with aspirin, inflammation, antagonist and cinod
9) Confidence 0.68 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.64 Pain Relevance 0.23
NF-kappaB activity is elevated in a high proportion of cancers, particularly advanced cancers that have been treated previously.
Positive_regulation (elevated) of NF-kappaB associated with cancer
10) Confidence 0.68 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.46 Pain Relevance 0
Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events.
Positive_regulation (activation) of NF-kappaB in Hepa 1-6 associated with paracetamol
11) Confidence 0.68 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.16 Pain Relevance 0.89
We recently reported that APAP likewise inhibits serum growth factor activation of NF-kappaB in a mouse hepatoma cell line (Hepa 1-6 cells).
Positive_regulation (activation) of NF-kappaB in Hepa 1-6 associated with paracetamol and hepatocellular cancer
12) Confidence 0.68 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.19 Pain Relevance 0.73
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Positive_regulation (activation) of NF-kappaB in skin associated with qutenza
13) Confidence 0.68 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.57
Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation.
Positive_regulation (transactivation) of NF-kappaB in skin associated with inflammation and qutenza
14) Confidence 0.68 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.25 Pain Relevance 0.59
Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis.
Positive_regulation (activation) of NF-kappaB in epidermis associated with qutenza
15) Confidence 0.68 Published 2001 Journal Cancer Lett. Section Title Doc Link 11179825 Disease Relevance 0.19 Pain Relevance 0.70
Although we have shown in a previous study the therapeutic effect of lornoxicam on corneal damage after high intensity UVB irradiation via inhibition of NF-kB activation, the concrete mediators and detailed mechanisms between NF-?
Positive_regulation (activation) of NF-kB
16) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697669 Disease Relevance 0.65 Pain Relevance 0.03
CIH led to lipid peroxidation of liver tissue with a malondialdehyde (MDA)/free fatty acids (FFA) ratio of 0.54 +/- 0.07 mmol/mol versus 0.30 +/- 0.01 mmol/mol in control animals (P < 0.01), and increased levels of active nuclear factor kappaB (NF-kappaB) in the nuclear fraction of hepatocytes, suggesting that CIH induced oxidative stress in the liver.
Positive_regulation (increased) of NF-kappaB in hepatocytes associated with stress and hypoxia
17) Confidence 0.67 Published 2007 Journal Hepatology Section Abstract Doc Link 17393512 Disease Relevance 2.15 Pain Relevance 0.09
The cytosolic level of the activated form of nuclear factor-kappa B (NF-kappaB), which is a major contributor to the induction of COX-2, on the ipsilateral side of the mouse spinal cord was also increased compared with that in the saline-treated mice.
Positive_regulation (increased) of NF-kappaB in spinal cord associated with spinal cord
18) Confidence 0.67 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262365 Disease Relevance 0.91 Pain Relevance 0.73
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Positive_regulation (induced) of NF-kappaB associated with infection and morphine
19) Confidence 0.67 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.73 Pain Relevance 0.59
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Positive_regulation (induction) of NF-kappaB associated with infection and morphine
20) Confidence 0.67 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.78 Pain Relevance 0.58

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