INT270962

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 75 97.00 Very High Very High Very High
Dopamine 155 85.68 High High
Nucleus accumbens 5 20.12 Low Low
gABA 10 8.08 Low Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Neuropeptide 10 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cocaine 5 5.00 Very Low Very Low Very Low
Ventral tegmentum 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Drug Dependence 10 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Schizophrenia 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that this interaction leads to cell surface stabilization of DAT via reduced degradation, possibly through a reduction in DAT phosphorylation.
Spec (possibly) Negative_regulation (reduction) of Phosphorylation (phosphorylation) of DAT
1) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
CPE stablized DAT via reducing the phosphorylation state of DAT
Negative_regulation (reducing) of Phosphorylation (phosphorylation) of DAT
2) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.08
Reduced phosphorylation state of DAT might reflect that association of CPE with DAT leaded to the occlusion of PKC phosphorylation sites.
Negative_regulation (Reduced) of Phosphorylation (phosphorylation) of DAT associated with kinase c
3) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.20
This is in agreement with our studies in which CPE decreases DAT phosphorylation leading to slower degradation and increase cell surface localization.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of DAT
4) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.20
In addition, CPE association could reduce the phosphorylation state of DAT on serine residues, potentially leading to reduced internalization, thus stabilizing plasmalemmal DAT localization.


Negative_regulation (reduce) of Phosphorylation (phosphorylation) of DAT
5) Confidence 0.31 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.14

General Comments

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