INT27100

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.44
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb3) plasma membrane (Adrb3) nucleus (Adrb3)
signal transducer activity (Adrb3)
Anatomy Link Frequency
myocardium 1
brain 1
bladder 1
adipocytes 1
heart 1
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 22 100.00 Very High Very High Very High
anesthesia 2 100.00 Very High Very High Very High
agonist 13 99.64 Very High Very High Very High
Serotonin 1 99.12 Very High Very High Very High
adenocard 1 93.88 High High
Migraine 4 92.96 High High
potassium channel 1 92.52 High High
beta blocker 2 90.42 High High
Opioid 2 90.00 High High
Catecholamine 3 83.66 Quite High
Disease Link Frequency Relevance Heat
Obesity 5 100.00 Very High Very High Very High
Nicotine Addiction 4 100.00 Very High Very High Very High
Coronary Artery Disease 7 99.58 Very High Very High Very High
Infarction 1 96.60 Very High Very High Very High
Coronary Stenosis 1 94.82 High High
Disorder Of Lipid Metabolism 5 94.56 High High
Headache 4 92.96 High High
Heart Rate Under Development 2 90.48 High High
Urological Neuroanatomy 1 90.08 High High
Hypotension 2 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, [3H]cirazoline is a novel high affinity radioligand that specifically labels imidazoline recognition sites without significant alpha- or beta-adrenoceptor binding.
beta-adrenoceptor Binding (binding) of
1) Confidence 0.47 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677320 Disease Relevance 0 Pain Relevance 0.09
Haemodynamic interactions between alpha- and beta-adrenoceptor antagonists in conscious or anaesthetized rats.
beta-adrenoceptor Binding (interactions) of associated with anesthesia and antagonist
2) Confidence 0.47 Published 1980 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 6103770 Disease Relevance 0.18 Pain Relevance 0.24
The beta 3-adrenoceptor is now a recognized sub-type of beta-adrenoceptor and is the principle adrenoceptor responsible for lipolysis in rat adipocytes.
beta-adrenoceptor Binding (recognized) of in adipocytes associated with obesity
3) Confidence 0.37 Published 1996 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 8971281 Disease Relevance 0.38 Pain Relevance 0.33
Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.
beta-adrenoceptor Binding (binding) of in brain
4) Confidence 0.36 Published 1984 Journal J. Neural Transm. Section Title Doc Link 6325592 Disease Relevance 0.21 Pain Relevance 0.21
Interactions of carteolol and other beta-adrenoceptor blocking agents with serotonin receptor subtypes.
beta-adrenoceptor Binding (Interactions) of associated with serotonin
5) Confidence 0.34 Published 1989 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 2576893 Disease Relevance 0.34 Pain Relevance 0.39
The alpha- and beta-adrenoceptor antagonists that interact with various receptor subtypes are briefly discussed.
beta-adrenoceptor Binding (interact) of associated with antagonist
6) Confidence 0.23 Published 1988 Journal Am. Heart J. Section Abstract Doc Link 2903648 Disease Relevance 0.13 Pain Relevance 0.16
Goals for the perioperative management of patients with coronary artery disease include: * Prevent increases in sympathetic nervous system activity: reduce anxiety preoperatively; prevent stress response and release of catecholamines by appropriate use of opioids or volatile anesthetics and beta-adrenoceptor antagonists; beta-blocker therapy should be initiated before and continued during and after the surgical procedure. * Decrease heart rate: reduction in heart rate increases oxygen supply to ischemic myocardium and reduces oxygen demand; the use of beta-blockers is the most effective means to reduce or attenuate deleterious increases in heart rate. * Preserve coronary perfusion pressure: decreases in diastolic arterial pressure in the presence of severe coronary artery stenoses will lead to decreases in blood flow; preservation of perfusion pressure by administration of fluid or phenylephrine or a reduction in anesthetic concentration may be critical. * Decrease myocardial contractility: reduces myocardial oxygen demand and can be accomplished with beta-adrenoceptor antagonists or volatile anesthetics. * Precondition myocardium against stunning and infarction: in the future, this may accomplished by stimulating the adenosine triphosphate- dependent potassium channel with agents such as volatile anesthetics and opioid delta1-receptor agonists.
beta-adrenoceptor Binding (accomplished) of in myocardium associated with stress, coronary artery disease, catecholamine, anxiety disorder, coronary stenosis, adenocard, beta blocker, antagonist, agonist, potassium channel, infarction and opioid
7) Confidence 0.20 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10638923 Disease Relevance 0.51 Pain Relevance 0.57
The results suggest that, in the beta-adrenergic system, compounds with agonist and antagonist substituents on the same molecule exhibit properties of the substituent with the higher affinity for beta-adrenoceptor, and no agonist activity is evident when two antagonist pharmacophores are linked on the same molecule.
beta-adrenoceptor Binding (affinity) of associated with antagonist and agonist
8) Confidence 0.13 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2880591 Disease Relevance 0 Pain Relevance 0.52
Characterization of beta-adrenoceptor subtype in bladder smooth muscle in cynomolgus monkey.
beta-adrenoceptor Binding (Characterization) of in bladder associated with anesthesia
9) Confidence 0.11 Published 2002 Journal Jpn. J. Pharmacol. Section Title Doc Link 11855669 Disease Relevance 0.15 Pain Relevance 0.50
The results strengthen the importance of lipoprotein aberrations as risk factors for coronary heart disease also if observed in association with obesity, smoking and treatment with beta-adrenoceptor blocking drugs.
beta-adrenoceptor Binding (association) of in heart associated with nicotine addiction, coronary artery disease and obesity
10) Confidence 0.08 Published 1985 Journal Atherosclerosis Section Abstract Doc Link 2859866 Disease Relevance 1.54 Pain Relevance 0.06

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