INT271000

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.70 Pain Relevance 0.18

endosome (HLA-DPB1) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1) plasma membrane (HLA-DPB1)

Anatomy Link Frequency nasal 1 HLA-DPB1 (Homo sapiens) Aia1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat aspirin 31 83.32 antagonist 5 67.20 Inflammation 5 54.08 cINOD 3 5.00 COX2 2 5.00 adenocard 1 5.00 Antihistamine 1 5.00

Disease Link Frequency Relevance Heat Asthma 69 100.00 Urticaria 20 86.64 Rhinitis 3 81.24 Pressure And Volume Under Development 42 75.36 Nasal Polyps 2 60.80 Chronic Sinusitis 1 60.00 INFLAMMATION 5 54.08 Hypersensitivity Pneumonitis 1 20.24 Anaphylaxis 1 18.56 Disease 1 13.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The association between HLA-DPB1*0301 and AIA was first reported in a Polish population,14 and the results were replicated in a Korean population.15 The frequency of DPB1*0301 was significantly higher in AIA patients compared to normal and asthmatic controls, suggesting that immune system recognition of an unknown antigen is part of the pathogenesis of AIA.14 In the Korean population,15 the patients with DPB1*0301 tended to have lower FEV1 levels, be female, and have a higher prevalence of rhinosinusitis and nasal polyps than those without it.

HLA-DPB1 Binding (association) of AIA in nasal associated with asthma and rhinitis

1) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.70 Pain Relevance 0.18

General Comments

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