The association between HLA-DPB1*0301 and AIA was first reported in a Polish population,14 and the results were replicated in a Korean population.15 The frequency of DPB1*0301 was significantly higher in AIA patients compared to normal and asthmatic controls, suggesting that immune system recognition of an unknown antigen is part of the pathogenesis of AIA.14 In the Korean population,15 the patients with DPB1*0301 tended to have lower FEV1 levels, be female, and have a higher prevalence of rhinosinusitis and nasal polyps than those without it.
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