INT271019

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.75
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp2a1) endoplasmic reticulum (Atp2a1)
Anatomy Link Frequency
hearts 1
reticulum 1
Atp2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 30 99.84 Very High Very High Very High
Central nervous system 1 53.76 Quite High
anesthesia 7 41.04 Quite Low
withdrawal 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 78 99.84 Very High Very High Very High
Myocardial Infarction 19 99.20 Very High Very High Very High
Hypoxia 78 88.36 High High
Coronary Heart Disease 48 86.48 High High
Synkinesis 1 63.20 Quite High
Breast Cancer 6 52.68 Quite High
Targeted Disruption 72 44.48 Quite Low
Cancer 12 43.44 Quite Low
Hyperplasia 6 35.68 Quite Low
Paralysis 5 35.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine whether a lower Ca2+ uptake was due to the down-regulation of SERCA1 (Ca2+ pump), western blot analysis was performed.
Spec (whether) Negative_regulation (regulation) of SERCA1
1) Confidence 0.19 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.06 Pain Relevance 0.03
Reduced calcium cycling from the sarcoplasmic reticulum, which we expect with reduced SERCA, could be responsible for both reducing contractility and maintaining the ATP:ADP ratio by reducing ATP consumption during the cardiac cycle.
Negative_regulation (reduced) of SERCA in reticulum
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.37 Pain Relevance 0.03
If re-uptake of calcium is depressed by reduced SERCA amount or activity, then reduced inotropy would be expected.
Negative_regulation (reduced) of SERCA
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.16 Pain Relevance 0
Our data further emphasizes the importance of reduced SERCA as a primary effector of cardiac contractility, and therefore a worthy target for such strategies.
Negative_regulation (reduced) of SERCA
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.42 Pain Relevance 0.05
Our transcriptional evaluation did indeed demonstrate substantial down-regulation of the mRNA for SERCA.
Negative_regulation (regulation) of SERCA
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.21 Pain Relevance 0
corresponds primarily to a reduced cellular activity of SERCA.


Negative_regulation (reduced) of SERCA
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0 Pain Relevance 0
In human hearts there is strong evidence for down-regulation of SERCA in ischemia[33]and heart failure[34].
Negative_regulation (regulation) of SERCA in hearts associated with ischemia and myocardial infarction
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.53 Pain Relevance 0.05

General Comments

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