INT271021

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.64 Pain Relevance 0.03

mitochondrion (Casq1) Golgi apparatus (Casq1) cytoplasm (Casq1)

Anatomy Link Frequency muscle 1 reticulum 1 Casq1 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 3 62.92 Central nervous system 3 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Disease 12 72.48 Eye Disease 6 71.12 Muscle Disease 3 70.16 Frailty 6 66.68 Paralysis 15 62.20 Heart Disease 3 60.08 Malignant Hyperthermia 3 53.44 Myasthenia Gravis 3 51.52 Paresis 9 47.56 Congenital Anomalies 3 14.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, we evaluated ryanodine receptor binding, Ca2+ uptake, the relation between SERCA and uptake, and calsequestrin (Ca2+ storage), in normal, primary IOOA, and secondary IOOA.

calsequestrin Binding (binding) of

1) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0

Calsequestrin is a Ca2+ storage protein that binds Ca2+ within the lumen of the sarcoplasmic reticulum.

Calsequestrin Binding (binds) of in reticulum

2) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.34 Pain Relevance 0.03

These include ryanodine receptor, a Ca2+ release channel which participates in Ca2+ release from sarcoplasmic reticulum into muscle cells, Ca2+-ATPase, which drives Ca2+ uptake, and calsequestrin that binds with Ca2+.8-11 Thus, since Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ release from the sarcoplasmic reticulum play key roles in the regulation of Ca2+ concentrations in muscle cells, the above proteins are important elements in studies on the mechanisms of muscle contraction and relaxation.

calsequestrin Binding (binds) of in muscle

3) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.30 Pain Relevance 0

General Comments

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