INT271083

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
BxPC-3 1
crypt cell 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 72.88 Quite High
spastic colon 1 51.60 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 15 97.06 Very High Very High Very High
Injury 2 96.16 Very High Very High Very High
Death 18 90.00 High High
Disease 7 88.84 High High
Apoptosis 33 68.48 Quite High
Gastrointestinal Disease 3 55.44 Quite High
Infection 1 52.48 Quite High
Functional Bowel Disorder 1 51.60 Quite High
Colon Cancer 1 49.20 Quite Low
Cancer 24 28.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, tyrosine phosphorylation of MAPK, MAPK-dependent increase in p21 (waf1/cip1), c-Myc, and c-Fos expression were found to be upstream events in growth factor induced crypt cell proliferation [6], [8], [9].
Phosphorylation (phosphorylation) of p21 in crypt cell
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.26 Pain Relevance 0.09
Therefore we examined the anticancer activities of [6]-gingerol, and investigated its mechanism in two different pancreatic cancer cell lines, HPAC with wt p53 or BxPC-3 with mutant p53. [6]-Gingerol's antiproliferative effects are associated with changes in the expression or phosphorylation of Cyclin A, Cdks, p21 and Rb, and most commonly, causes cell cycle arrest at the G1 phase.
Phosphorylation (phosphorylation) of p21 in BxPC-3 associated with pancreatic cancer
2) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.65 Pain Relevance 0

General Comments

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