INT271087

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna) transcription factor binding (Pcna) cytoplasm (Pcna)

Anatomy Link Frequency BxPC-3 1 Pcna (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 3 5.00 colic 1 5.00 neuralgia 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 15 97.06 Death 16 88.96 Disease 4 88.84 Apoptosis 32 68.48 Cancer 22 28.00 Adenocarcinoma 1 25.72 Intestinal Cancer 1 24.36 Malignant Neoplastic Disease 3 19.80 Sprains And Strains 1 16.16 Ulcers 1 15.60

Sentences Mentioned In

Key:

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Mutation

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Anatomy

Negation

Speculation

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Disease term

Therefore we examined the anticancer activities of [6]-gingerol, and investigated its mechanism in two different pancreatic cancer cell lines, HPAC with wt p53 or BxPC-3 with mutant p53. [6]-Gingerol's antiproliferative effects are associated with changes in the expression or phosphorylation of Cyclin A, Cdks, p21 and Rb, and most commonly, causes cell cycle arrest at the G1 phase.

Phosphorylation (phosphorylation) of Cyclin in BxPC-3 associated with pancreatic cancer

1) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.65 Pain Relevance 0

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