INT271096

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0

cytoplasm (Pcna, Akt1) nucleus (Pcna, Akt1) transport (Akt1) aging (Akt1) intracellular (Pcna) enzyme binding (Akt1)

Pcna (Mus musculus) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 3 5.00 colic 1 5.00 neuralgia 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Cancer 22 98.52 Dna Damage 1 78.88 Stress 2 68.80 Death 16 50.00 Pancreatic Cancer 15 50.00 Apoptosis 32 38.80 Malignant Neoplastic Disease 3 34.80 Disease 4 5.00 INFLAMMATION 3 5.00 Skin Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, the levels of Cyclins, Cyclin-dependent kinases, their inhibitors, or the status of tumor suppressor genes such as p53 and Rb, that are all involved in cell cycle regulation, may determine whether a chemical inhibitor (drug) results in cell cycle arrest or not.

Cyclin Positive_regulation (dependent) of kinases associated with cancer

1) Confidence 0.00 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.