INT27115

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.01
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
corpus callosum 1
T-cells 1
cerebellum 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 67 94.16 High High
Neuritis 2 93.32 High High
midbrain 1 91.16 High High
Hippocampus 14 81.72 Quite High
anesthesia 7 77.32 Quite High
Inflammatory response 6 75.36 Quite High
Neurotransmitter 27 67.52 Quite High
Inflammation 49 50.00 Quite Low
agonist 22 47.04 Quite Low
unmyelinated 3 40.24 Quite Low
Disease Link Frequency Relevance Heat
Encephalitis 1 100.00 Very High Very High Very High
Herpes Simplex Virus 1 100.00 Very High Very High Very High
Parainfluenza Virus Infection 1 100.00 Very High Very High Very High
Cytomegalovirus Infection 1 100.00 Very High Very High Very High
Measles 1 100.00 Very High Very High Very High
Togavirus Infection 1 100.00 Very High Very High Very High
Influenza Virus Infection 1 100.00 Very High Very High Very High
Multiple Sclerosis 234 97.32 Very High Very High Very High
Demyelinating Disease 120 94.16 High High
Optic Neuritis 1 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For each lane, there is a ratio of MBP product/?
MBP Binding (ratio) of
1) Confidence 0.31 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.18
(B) Upon quantification, myelin basic protein immunoreactivity in the corpus callosum was significantly lower in vehicle-treated EAE mice as compared to normal mice, while oestrogen receptor ?
myelin basic protein Binding (immunoreactivity) of in corpus callosum associated with multiple sclerosis
2) Confidence 0.31 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.90 Pain Relevance 0
This mechanism reduces the ability of MBP/MHC complexes to bind to and activate myelin reactive T-cells [33].
MBP Binding (bind) of in T-cells
3) Confidence 0.27 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 0.70 Pain Relevance 0
These lesions of the cerebellum were most severely demyelinated judged by MBP immunostaining (Fig. 2D, G).
MBP Binding (judged) of in cerebellum
4) Confidence 0.19 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.39 Pain Relevance 0.21
VLD) as an MBP fusion protein and examined the interaction between MBP-tomosyn-?
MBP Spec (examined) Binding (interaction) of
5) Confidence 0.18 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
organization, myelin basic protein (MBP)
MBP Binding (organization) of
6) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0 Pain Relevance 0
C) reduced their binding affinity for MBP–PDZ123 and that these 11 amino acids (CT11) can bind to MBP–PDZ123 (Figure 6D).
MBP Binding (affinity) of
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
C) reduced their binding affinity for MBP–PDZ123 and that these 11 amino acids (CT11) can bind to MBP–PDZ123 (Figure 6D).
MBP Binding (binding) of
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0 Pain Relevance 0
So far, screening of these Ig subpopulations for reaction with several viruses (measles, parainfluenza type 1, influenza type A, cytomegalovirus, herpes simplex virus, rubella virus, poliovirus, murine encephalomyelitis viruses, and reovirus) and myelin basic protein has failed to reveal their antigen specificities.
myelin basic protein Binding (screening) of associated with herpes simplex virus, influenza virus infection, measles, encephalitis, togavirus infection, cytomegalovirus infection and parainfluenza virus infection
9) Confidence 0.05 Published 1985 Journal J. Immunol. Section Abstract Doc Link 2578510 Disease Relevance 1.03 Pain Relevance 0.09

General Comments

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