INT27118

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.18
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
SH-SY5Y 2
brain 2
auditory receptor cell 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 66 100.00 Very High Very High Very High
Morphine 19 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
cocaine 1 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
Opioid 3 99.84 Very High Very High Very High
noradrenaline 3 99.00 Very High Very High Very High
narcan 5 98.04 Very High Very High Very High
potassium channel 1 95.48 Very High Very High Very High
Enkephalin 4 94.40 High High
Disease Link Frequency Relevance Heat
Nociception 2 88.88 High High
Neuroblastoma 2 84.24 Quite High
Deafness 77 82.24 Quite High
Disease 85 73.28 Quite High
Depression 2 61.52 Quite High
Nicotine Addiction 90 59.08 Quite High
Adverse Drug Reaction 2 51.52 Quite High
Syndrome 5 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failure of naloxone to inhibit morphine-induced histamine release suggests that histamine release by morphine is not dependent on opiate receptor binding or activation.
Neg (not) Regulation (dependent) of opiate receptor Binding (binding) of associated with narcan, opiate and morphine
1) Confidence 0.62 Published 1985 Journal Anesthesiology Section Abstract Doc Link 2578752 Disease Relevance 0 Pain Relevance 1.14
Gender and age influences on human brain mu-opioid receptor binding measured by PET.
Regulation (influences) of mu-opioid receptor Binding (binding) of in brain associated with opioid receptor
2) Confidence 0.53 Published 1999 Journal Am J Psychiatry Section Title Doc Link 10360121 Disease Relevance 0 Pain Relevance 0.26
In addition, co-immunoprecipitation experiments revealed evidence for an interaction between MOR and mGluR5 which is facilitated by MPEP treatment.
Regulation (facilitated) of MOR Binding (interaction) of associated with opioid receptor
3) Confidence 0.42 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.73
M of each OPRM1 and control primer, approximately 150 ng of DNA, 200 ?
Regulation (control) of OPRM1 Binding (primer) of
4) Confidence 0.39 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2996370 Disease Relevance 0.23 Pain Relevance 0.10
Furthermore, the role of these phosphorylation sites in regulating the internalization of MOR was investigated.
Regulation (regulating) of MOR Binding (internalization) of associated with opioid receptor
5) Confidence 0.39 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278523 Disease Relevance 0 Pain Relevance 0.54
Effects of morphine and its metabolites on opiate receptor binding, cAMP formation and [3H]noradrenaline release from SH-SY5Y cells.
Regulation (Effects) of opiate receptor Binding (binding) of in SH-SY5Y associated with noradrenaline, opiate and morphine
6) Confidence 0.25 Published 1993 Journal Biochem. Pharmacol. Section Title Doc Link 8216364 Disease Relevance 0.08 Pain Relevance 1.00
Although NK1-MOR1 heterodimerization did not substantially change the ligand binding and signaling properties of these receptors, it dramatically altered their internalization and resensitization profile.
Neg (not) Regulation (change) of NK1-MOR1 Binding (heterodimerization) of associated with opioid receptor
7) Confidence 0.24 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.09 Pain Relevance 0.63
Although NK1-MOR1 heterodimerization did not substantially change the ligand binding and signaling properties of these receptors, it dramatically altered their internalization and resensitization profile.
Neg (not) Regulation (change) of NK1-MOR1 Binding (heterodimerization) of associated with opioid receptor
8) Confidence 0.24 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.09 Pain Relevance 0.63
The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor.
Regulation (modulated) of mu-opioid receptor Binding (binding) of associated with opioid receptor and opioid
9) Confidence 0.23 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 16580639 Disease Relevance 0.06 Pain Relevance 0.73
As for the candidate genes, the enriched terms, divided into biological processes, molecular functions and cellular components (Table 4), include expected concepts such as “auditory receptor cell stereocilium organization” (GO:0060088), “large conductance calcium-activated potassium channel activity” (GO:0060072), “sensory perception of sound” (GO:0007605), “auditory receptor cell stereocilium organization” (GO:0060088), consistent with hearing physiology, as well as less obvious functions or processes such as “regulation of circadian sleep/wake cycle, REM and non-REM sleep” (GO:0042320, GO:0045188), “response to cocaine” (GO:0042220), or “mu-type opioid receptor binding” (GO:0031852), that need further (experimental) investigations.
Regulation (regulation) of mu-type opioid receptor Binding (binding) of in auditory receptor cell associated with opioid receptor 1, potassium channel and cocaine
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2946934 Disease Relevance 0.62 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox