INT271193

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Creb1 (Mus musculus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 32 100.00 Very High Very High Very High
Desipramine 4 96.84 Very High Very High Very High
adenocard 1 86.92 High High
antidepressant 114 85.84 High High
depression 84 82.16 Quite High
monoamine 3 81.32 Quite High
sSRI 20 77.92 Quite High
Hippocampus 17 76.76 Quite High
fluoxetine 30 51.80 Quite High
Kappa opioid receptor 1 45.28 Quite Low
Disease Link Frequency Relevance Heat
Depression 91 82.16 Quite High
Targeted Disruption 27 77.44 Quite High
Urological Neuroanatomy 4 60.28 Quite High
Frailty 1 42.32 Quite Low
Stress 10 28.72 Quite Low
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Hypothermia 3 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF itself is a target gene regulated by CREB [56, 77, 78] and abolition of BDNF up-regulation has been observed in chronic desipramine treated CREB deficient mice [57].
CREB Regulation (regulated) of BDNF associated with desipramine and bdmf
1) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.28 Pain Relevance 0.81

General Comments

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