INT271205

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.38
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TNFRSF1B) extracellular region (TNFRSF1B) plasma membrane (TNFRSF1B)
Anatomy Link Frequency
pituitary 1
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 99.12 Very High Very High Very High
cytokine 63 97.96 Very High Very High Very High
Inflammatory mediators 1 56.40 Quite High
depression 23 50.00 Quite Low
Pain 2 12.08 Low Low
Neuropathic pain 1 9.44 Low Low
Serotonin 13 5.00 Very Low Very Low Very Low
antidepressant 10 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 99.68 Very High Very High Very High
INFLAMMATION 41 99.12 Very High Very High Very High
Disease 13 92.16 High High
Obesity 19 88.64 High High
Stroke 1 81.96 Quite High
Brain Hemorrhage 1 80.32 Quite High
Cardiovascular Disease 1 78.76 Quite High
Stress 1 67.12 Quite High
Cancer 4 57.68 Quite High
Depression 29 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and its soluble receptors p55 and p75 — released during infection and inflammation activate the HPA system at the hypothalamic, pituitary, and adrenal level resulting in the release of cortisol as the most important negative feedback signal to prevent an overshoot of the ongoing host defense [42, 89, 96]; glucocorticoids, in turn, suppress the production of pro-inflammatory cytokines.
Localization (released) of p75 in pituitary associated with inflammation, infection and cytokine
1) Confidence 0.26 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.38 Pain Relevance 0.54

General Comments

This test has worked.

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