INT27123

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pomc, Cck) extracellular region (Pomc, Cck) signal transduction (Pomc)
generation of precursor metabolites and energy (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
brain 2
Pomc (Rattus norvegicus)
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 6 100.00 Very High Very High Very High
Enkephalin 6 99.52 Very High Very High Very High
substance P 2 98.80 Very High Very High Very High
narcan 3 98.54 Very High Very High Very High
Endogenous opioid 4 94.36 High High
opiate 3 89.36 High High
antagonist 2 80.60 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain cholecystokinin and beta-endorphin systems may antagonistically interact to regulate tissue DNA synthesis in rat pups.
beta-endorphin Binding (interact) of cholecystokinin in Brain associated with cholecystokinin
1) Confidence 0.31 Published 1994 Journal Brain Res. Section Title Doc Link 7834370 Disease Relevance 0 Pain Relevance 0.27
Thus, normal mammalian development may require a close functional interaction between the cholecystokinin and beta-endorphin systems in the brain.
beta-endorphin Binding (interaction) of cholecystokinin in brain associated with cholecystokinin
2) Confidence 0.31 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834370 Disease Relevance 0 Pain Relevance 0.31
Dissociated acini were incubated with naloxone, substance P, VIP, (Met)5- and (Leu)5-enkephalin and alpha-, beta-, and gamma-endorphin alone or in combination with CCK8.
gamma-endorphin Binding (combination) of CCK8 associated with narcan, enkephalin and substance p
3) Confidence 0.05 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 2578922 Disease Relevance 0 Pain Relevance 0.80

General Comments

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