INT271262

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 79.52 Quite High
Inflammation 14 61.04 Quite High
Inflammatory response 2 58.80 Quite High
antagonist 1 54.64 Quite High
cINOD 1 24.40 Low Low
Inflammatory mediators 1 10.00 Low Low
Bile 9 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dna Damage 10 98.32 Very High Very High Very High
Cancer 96 92.24 High High
Alzheimer's Dementia 2 89.20 High High
Apoptosis 20 61.04 Quite High
INFLAMMATION 16 61.04 Quite High
Pressure And Volume Under Development 1 59.60 Quite High
Injury 1 43.52 Quite Low
Metastasis 19 5.00 Very Low Very Low Very Low
Obesity 14 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable knockdown of STAT1 reversed the aggressive phenotype and decreased both lung colonization and resistance to genotoxic stress.


Negative_regulation (decreased) of Negative_regulation (knockdown) of STAT1 in lung associated with dna damage
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.94 Pain Relevance 0
may downregulate gene expression by causing the loss of STAT1 and STAT3 binding to DNA [12].
Negative_regulation (causing) of Negative_regulation (loss) of STAT1
2) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.46 Pain Relevance 0.18

General Comments

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