INT27133

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2007
Negated 3
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.74
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfkbiz)
Anatomy Link Frequency
neurons 2
dorsal 1
suture 1
ventral 1
Nfkbiz (Mus musculus)
Pain Link Frequency Relevance Heat
Neurolysis 1 97.72 Very High Very High Very High
Nav1.1 1 92.88 High High
Nav1.2 1 92.24 High High
Nav1.6 1 91.36 High High
nav1.3 1 90.08 High High
tetrodotoxin 8 89.60 High High
lidocaine 1 89.60 High High
nav1.8 1 87.92 High High
antagonist 2 77.72 Quite High
GABAergic 2 77.24 Quite High
Disease Link Frequency Relevance Heat
Neuroma 2 99.00 Very High Very High Very High
Injury 5 95.28 Very High Very High Very High
Targeted Disruption 1 81.52 Quite High
Peripheral Nervous System Neoplasms 1 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If an INAP is absent, resection of the dense neuroma is usually undertaken with end-to-end suture or graft.
Neg (absent) Gene_expression (absent) of INAP in suture associated with neuroma
1) Confidence 0.60 Published 1988 Journal Neurol Clin Section Abstract Doc Link 3070345 Disease Relevance 0.66 Pain Relevance 0.14
Ventral bursting cells possessed both hyperpolarization-activated current (Ih) and persistent sodium current (INaP), whereas dorsal and ventral nonbursting cells possessed Ih but no INaP.
Neg (no) Gene_expression (possessed) of INaP in dorsal
2) Confidence 0.59 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12713637 Disease Relevance 0 Pain Relevance 0.24
Indirect evidence suggests that INaP is present and large during prolonged depolarizations greater than 50 mV positive to RP.
Gene_expression (present) of INaP
3) Confidence 0.32 Published 1985 Journal J. Neurophysiol. Section Abstract Doc Link 2579215 Disease Relevance 0 Pain Relevance 0.29
INaT, INaR and INaP Na+ currents with properties similar to those observed in acutely isolated Purkinje neurons were detected in nucleated outside-out patches from cultured Purkinje cells.
Gene_expression (detected) of INaP in neurons
4) Confidence 0.29 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.08 Pain Relevance 0.56
In the present study we investigate the expression of a persistent Na+ conductance (INaP) in identified medium-sized neostriatal neurons.
Spec (investigate) Gene_expression (expression) of INaP in neurons
5) Confidence 0.27 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7500155 Disease Relevance 0 Pain Relevance 0.03
Ventral bursting cells possessed both hyperpolarization-activated current (Ih) and persistent sodium current (INaP), whereas dorsal and ventral nonbursting cells possessed Ih but no INaP.
Neg (no) Gene_expression (possessed) of INaP in ventral
6) Confidence 0.20 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12713637 Disease Relevance 0 Pain Relevance 0.24

General Comments

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