INT271362

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.16
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PIGF)
Anatomy Link Frequency
chest 1
PIGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 136 97.28 Very High Very High Very High
Inflammation 76 68.92 Quite High
Inflammatory marker 4 56.44 Quite High
ischemia 96 53.12 Quite High
metalloproteinase 20 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 84 99.52 Very High Very High Very High
Acute Coronary Syndrome 280 99.36 Very High Very High Very High
Atherosclerosis 20 99.08 Very High Very High Very High
Urological Neuroanatomy 112 98.12 Very High Very High Very High
Rupture 32 97.72 Very High Very High Very High
Angina 136 97.28 Very High Very High Very High
Natriuresis 44 95.12 Very High Very High Very High
Emergencies 20 88.92 High High
Necrosis 92 81.76 Quite High
Myocardial Infarction 164 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, elevated PIGF levels identified not only patients with ACS presenting with acute chest pain, but also patients with an increased risk of recurrent instability after discharge.
Positive_regulation (elevated) of PIGF in chest associated with acute coronary syndrome and angina
1) Confidence 0.19 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.00 Pain Relevance 0.25
In the CAPTURE cohort, 40.8% patients were found to have increased PIGF concentrations and were found to have a markedly increased risk of adverse events at 30 days; also in the other cohort, PIGF was a predictor of increase in risk.
Positive_regulation (increased) of PIGF
2) Confidence 0.19 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.01 Pain Relevance 0.22
In this study MPO, sCD40L and MMP-9 levels were not independently associated with death, whereas patients with increased levels of PIGF, NT-proBNP, CRP, cTnI or decreased eGFR had higher mortality rate than patients with normal value of these biomarkers.
Positive_regulation (increased) of PIGF associated with urological neuroanatomy and death
3) Confidence 0.13 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.16 Pain Relevance 0
Placental growth factor (PIGF), a member of the vascular endothelial growth factor (VEGF) family, was shown to be profoundly upregulated in early and advanced atherosclerotic lesions (Luttun A et al. 2002).
Positive_regulation (upregulated) of PIGF associated with atherosclerosis
4) Confidence 0.13 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.98 Pain Relevance 0.06

General Comments

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