INT271374

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 1.87
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Tymp)
Anatomy Link Frequency
internal 1
Tymp (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 260 99.82 Very High Very High Very High
cytokine 12 83.28 Quite High
Kinase C 13 70.56 Quite High
Angina 13 48.80 Quite Low
antagonist 13 36.76 Quite Low
Paracetamol 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 212 99.48 Very High Very High Very High
Hypersensitivity 15 96.32 Very High Very High Very High
Toxicity 30 89.00 High High
Adhesions 23 88.40 High High
Hepatotoxicity 8 81.76 Quite High
Cv General 3 Under Development 13 48.80 Quite Low
Coronary Artery Disease 13 47.72 Quite Low
Atherosclerosis 13 45.56 Quite Low
Increased Venous Pressure Under Development 26 38.80 Quite Low
Shock 4 38.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, proteins involved in biosynthesis of steroids (Hmger), cell cycle (Mcm5 and Mee), fatty acid biosynthesis (Fasn), glutathione metabolism (Gstm3), glycerolipid metabolism (Lipg), glycolysis (Pklr), gluconeogenesis, MAPK signaling pathways (Hspa1a) and purine metabolism (Ecgf1) were found to be induced by benzene.
Localization (metabolism) of Ecgf1
1) Confidence 0.23 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.42 Pain Relevance 0.04
Interestingly, proteins involved in biosynthesis of steroids (Hmger), cell cycle (Mcm5 and Mee), fatty and biosynthesis (Fasn), glutathione metabolism (Gstm3), glycerolipid metabolism (Lipg), glycolysis (Pklr), gluconeogenesis, MAPK signaling pathways (Hspa1a) and purine metabolism (Ecgf1) were found to be induced by benzene.
Localization (metabolism) of Ecgf1
2) Confidence 0.23 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.15 Pain Relevance 0.10
It should be noted that the repeat stimulation experiment was performed after translocation of TP?
Localization (translocation) of TP
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.03
Secondly, translocation of TP?
Localization (translocation) of TP
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.05 Pain Relevance 0
Firstly, both internal and surface pools of TP?
Localization (pools) of TP in internal
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.06 Pain Relevance 0
Brief hydrogen peroxide exposure increases the efficiency of translocation of TP?
Localization (translocation) of TP
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939892 Disease Relevance 0.07 Pain Relevance 0
Agonist-induced internalization of TP?
Localization (internalization) of TP associated with agonist
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.09 Pain Relevance 0.08
In cells exposed to H2O2 there is significant stabilization of TP?
Localization (stabilization) of TP
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.05 Pain Relevance 0
and also by demonstration of translocation to the surface of TP?
Localization (translocation) of TP
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
Taken together with the data above, these observations indicate that H2O2 leads to translocation of TP?
Localization (translocation) of TP
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
Biotinylation and immunofluorescence microscopy demonstrated rapid and prolonged relocation of TP?
Localization (relocation) of TP
11) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.28 Pain Relevance 0
In summary, a single, brief oxidative insult is sufficient to induce rapid and persistent translocation of TP?
Localization (translocation) of TP
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.17 Pain Relevance 0.24
Previously, using COS-7 cells that naturally express TP receptor, we demonstrated that brief exposure to hydrogen peroxide, as a model for acute oxidative stress, significantly increased translocation of TP?
Localization (translocation) of TP associated with stress
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.19 Pain Relevance 0.04
Translocation of TP?
Localization (Translocation) of TP
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.18 Pain Relevance 0.03
Further, we wished to determine the rate of translocation of TP?
Localization (translocation) of TP
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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