INT271376

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) response to stress (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
hepatocytes 1
Hspa1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 99.68 Very High Very High Very High
agonist 54 92.56 High High
Bile 5 91.80 High High
cytokine 53 82.72 Quite High
Inflammation 66 49.36 Quite Low
Inflammatory mediators 3 48.72 Quite Low
tolerance 7 41.20 Quite Low
Inflammatory response 15 30.96 Quite Low
chemokine 10 10.32 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 99.68 Very High Very High Very High
Reperfusion Injury 11 99.32 Very High Very High Very High
Toxicity 15 89.76 High High
Adhesions 12 87.84 High High
Targeted Disruption 2 86.40 High High
Hepatotoxicity 7 82.52 Quite High
Hepatitis 5 82.32 Quite High
Hepatitis C Virus Infection 10 80.80 Quite High
Alzheimer's Dementia 2 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, proteins involved in biosynthesis of steroids (Hmger), cell cycle (Mcm5 and Mee), fatty acid biosynthesis (Fasn), glutathione metabolism (Gstm3), glycerolipid metabolism (Lipg), glycolysis (Pklr), gluconeogenesis, MAPK signaling pathways (Hspa1a) and purine metabolism (Ecgf1) were found to be induced by benzene.
Localization (metabolism) of Hspa1a
1) Confidence 0.53 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.42 Pain Relevance 0.04
Endogenous TLR4 ligands such as extracellular HSP72, a strongly stress-inducible 72-kDa protein that is released during ischemia-reperfusion injury (IRI), can stimulate hepatocytes to produce MIP-2, IL-6 and TNF-?
Localization (released) of HSP72 in hepatocytes associated with stress, reperfusion injury and ischemia
2) Confidence 0.21 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.07 Pain Relevance 0.35

General Comments

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