INT2714

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Context Info
Confidence 0.79
First Reported 1979
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 0.50
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Prl) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 4
neuronal 2
neurons 2
lactotroph 2
Pomc (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 27 100.00 Very High Very High Very High
narcan 20 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Neuropeptide 10 99.98 Very High Very High Very High
Opioid 18 99.76 Very High Very High Very High
Dopamine 38 99.56 Very High Very High Very High
opiate 21 99.48 Very High Very High Very High
Endogenous opioid 2 99.16 Very High Very High Very High
Nicotine 5 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 53 99.66 Very High Very High Very High
Galactorrhea 8 79.68 Quite High
Obesity 4 28.40 Quite Low
Adenoma 5 17.36 Low Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well known that the opiate peptides, especially the pro-opiomelanocortin (POMC)-related peptide beta-endorphin, stimulate the release of prolactin (PRL) in the rat.
beta-endorphin Positive_regulation (stimulate) of Localization (release) of prolactin associated with opiate
1) Confidence 0.79 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475014 Disease Relevance 0.08 Pain Relevance 0.12
It is well known that the opiate peptides, especially the pro-opiomelanocortin (POMC)-related peptide beta-endorphin, stimulate the release of prolactin (PRL) in the rat.
beta-endorphin Positive_regulation (stimulate) of Localization (release) of PRL associated with opiate
2) Confidence 0.57 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475014 Disease Relevance 0.08 Pain Relevance 0.12
It is well known that the opiate peptides, especially the pro-opiomelanocortin (POMC)-related peptide beta-endorphin, stimulate the release of prolactin (PRL) in the rat.
pro-opiomelanocortin Positive_regulation (stimulate) of Localization (release) of prolactin associated with opiate
3) Confidence 0.46 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475014 Disease Relevance 0.08 Pain Relevance 0.12
Our results indicate, that under certain conditions (e.g. stress) the stimulated secretion of prolactin could be mediated partially by a direct action of pituitary beta-endorphin at the lactotroph.
beta-endorphin Positive_regulation (mediated) of Localization (secretion) of prolactin in lactotroph associated with stress
4) Confidence 0.42 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319905 Disease Relevance 0.10 Pain Relevance 0.51
A dose response study for beta-endorphin indicated that beta-endorphin, at doses as low as 25 ng, was a potent stimulus for prolactin release producing an increase in prolactin that mimicked the suckling-induced prolactin increase.
beta-endorphin Positive_regulation (stimulus) of Localization (release) of prolactin
5) Confidence 0.35 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8413824 Disease Relevance 0 Pain Relevance 0.40
These results indicate that beta-endorphin is a potent stimulus for prolactin secretion and that these three opiate receptor subtypes interact to produce its stimulatory effect on prolactin release.
beta-endorphin Positive_regulation (stimulus) of Localization (secretion) of prolactin associated with opiate
6) Confidence 0.35 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8413824 Disease Relevance 0 Pain Relevance 0.40
Pilocarpine also inhibited the release of prolactin induced by beta-endorphin or metoclopramide without affecting the basal and haloperidol-stimulated serum prolactin levels.
beta-endorphin Positive_regulation (induced) of Localization (release) of prolactin
7) Confidence 0.33 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 503252 Disease Relevance 0 Pain Relevance 0.50
It is suggested that gamma-endorphin increases prolactin secretion by interfering with dopaminergic systems in the pituitary and that DT gamma E and DE gamma E have a modulatory action on prolactin secretion.
gamma-endorphin Positive_regulation (increases) of Localization (secretion) of prolactin in pituitary
8) Confidence 0.32 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6184642 Disease Relevance 0 Pain Relevance 0.48
These results suggest that the central cholinergic system exertes an inhibitory influence on the prolactin release induced by morphine or beta-endorphin and the cholinergic inhibition is not mediated via catecholaminergic neurons.
beta-endorphin Positive_regulation (induced) of Localization (release) of prolactin in neurons associated with morphine
9) Confidence 0.22 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 503252 Disease Relevance 0 Pain Relevance 0.57
Previous studies have shown that exogenously administered opioids, including beta-endorphin, stimulate prolactin release.
beta-endorphin Positive_regulation (stimulate) of Localization (release) of prolactin associated with opioid
10) Confidence 0.22 Published 1981 Journal Endocrinology Section Abstract Doc Link 6271542 Disease Relevance 0.17 Pain Relevance 0.40
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-endorphin Positive_regulation (induce) of Localization (release) of PRL associated with dynorphin, enkephalin and morphine
11) Confidence 0.18 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-endorphin Positive_regulation (induce) of Localization (release) of prolactin associated with dynorphin, enkephalin and morphine
12) Confidence 0.18 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Other investigators also found N-POMC increases PRL and GH mRNA expression and stimulates PRL and GH secretion (after 12 h of treatment) in frog pituitary cell cultures (165).
N-POMC Positive_regulation (stimulates) of Localization (secretion) of PRL in pituitary
13) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.10
Endogenous opioid peptides (EOPs), mainly the neuropeptide beta-endorphin, facilitate PRL secretion by decreasing TIDA neuronal inhibitory tone in a number of physiological conditions, including pregnancy and lactation.
beta-endorphin Positive_regulation (facilitate) of Localization (secretion) of PRL in neuronal associated with neuropeptide and endogenous opioid
14) Confidence 0.11 Published 2004 Journal Endocrine Section Abstract Doc Link 15711026 Disease Relevance 0 Pain Relevance 0.54
Infusion of DA had no effect on the release of PRL induced by intracerebroventricularly administered beta-endorphin.
beta-endorphin Neg (no) Positive_regulation (induced) of Localization (release) of PRL associated with dopamine
15) Confidence 0.10 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320031 Disease Relevance 0 Pain Relevance 1.06
Suckling-induced prolactin release is suppressed by naloxone and simulated by beta-endorphin.
beta-endorphin Positive_regulation (simulated) of Localization (release) of prolactin associated with narcan
16) Confidence 0.07 Published 1986 Journal Neuroendocrinology Section Title Doc Link 2936973 Disease Relevance 0 Pain Relevance 0.71
Both beta-endorphin and enkephalins are capable of stimulating GH and PRL release in anesthetized and unanesthetized, freely moving rats.
beta-endorphin Positive_regulation (stimulating) of Localization (release) of PRL associated with enkephalin
17) Confidence 0.05 Published 1981 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 7010947 Disease Relevance 0 Pain Relevance 0.88

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