INT27144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.48
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Dct) isomerase activity (Dct) cytosol (Dct)
oxidoreductase activity (Dct) cytoplasm (Dct)
Anatomy Link Frequency
sympathetic 1
Dct (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 35 100.00 Very High Very High Very High
analgesia 1 98.64 Very High Very High Very High
Central nervous system 1 87.68 High High
Intracerebroventricular 1 83.84 Quite High
Opioid 1 75.68 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Anaphylaxis 5 100.00 Very High Very High Very High
Shock 2 94.84 High High
Microphthalmia 6 88.00 High High
Experimental Melanoma 2 84.52 Quite High
Skin Cancer 51 81.28 Quite High
Stress 15 75.00 Quite High
Adhesions 1 66.12 Quite High
Repression 6 26.00 Quite Low
Metastasis 11 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-anaphylactic action of DT gamma E as well as its effect to block the pro-anaphylactic action of beta-endorphin were prevented by pretreatment with the sympathetic ganglionic blocker, chlorisondamine chloride.
Negative_regulation (prevented) of DT gamma E in sympathetic associated with anaphylaxis
1) Confidence 0.16 Published 1985 Journal Brain Res. Section Abstract Doc Link 2579712 Disease Relevance 0.62 Pain Relevance 0.26
Inhibition of enzyme activities reflected decreased protein levels. mRNAs for tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, silver protein and melanocortin 1 receptor also decreased after H(2)O(2) treatment, and recovered at different rates.
Negative_regulation (decreased) of dopachrome tautomerase associated with melanocortin 1 receptor
2) Confidence 0.12 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.40 Pain Relevance 0.10
Inhibition of enzyme activities reflected decreased protein levels. mRNAs for tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, silver protein and melanocortin 1 receptor also decreased after H(2)O(2) treatment, and recovered at different rates.
Negative_regulation (decreased) of dopachrome tautomerase associated with melanocortin 1 receptor
3) Confidence 0.12 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.40 Pain Relevance 0.10
Approximately 10% of the genes downregulated in Mc1re/Mc1re animals were also downregulated in KitW-v/KitW-v animals (Figure 4C), including two genes required for eumelanogenesis, Dopachrome tautomerase and Silver.
Negative_regulation (downregulated) of Dopachrome tautomerase
4) Confidence 0.09 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox