INT271456

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.07
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
superior sagittal sinus 1
Gd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 370 99.80 Very High Very High Very High
b2 receptor 295 99.44 Very High Very High Very High
bradykinin 360 98.86 Very High Very High Very High
imagery 56 98.40 Very High Very High Very High
Thalamus 15 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 463 73.56 Quite High
Cancer 605 64.36 Quite High
Brain Tumor 244 50.00 Quite Low
Malignant Neoplastic Disease 60 50.00 Quite Low
Solid Tumor 40 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 5 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From each of the Gd-dendrimer stock solutions to be used for in vivo imaging, 20 ?
Regulation (each) of Gd-dendrimer associated with imagery
1) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0 Pain Relevance 0.15
The change, over time, in blood Gd-DTPA concentration was measured in the superior sagittal sinus, which is a large caliber vein in the rat brain.
Regulation (change) of Gd-DTPA in superior sagittal sinus
2) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.29 Pain Relevance 0.38
Blood half-life of Gd-DTPA as a result of the infusion of bradykinin B2 receptor agonists
Regulation (result) of Gd-DTPA in Blood associated with agonist and b2 receptor
3) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.36 Pain Relevance 0.39
The change in blood Gd-DTPA concentration for the 1st hour of scanning, following the 1st Gd-DTPA bolus, was compared to that over the 2nd hour of scanning, following the 2nd Gd-DTPA bolus.
Regulation (change) of Gd-DTPA in blood
4) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.17 Pain Relevance 0.41
On post hoc analysis, in the BK group and Lys-BK group to NS group comparisons, there was no significant change in Gd-DTPA AUC (Figure 7C).
Neg (no) Regulation (change) of Gd-DTPA associated with bradykinin
5) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.26 Pain Relevance 0.44
The 15 minute intravenous infusion of NS, beginning 2 to 3 minutes prior to the 2nd Gd-DTPA bolus, had almost no effect on the blood half-life of Gd-DTPA, as evidenced by the similarities, over time, in the 1st and 2nd Gd-DTPA concentration curves in Figure 3, panel A.
Neg (no) Regulation (effect) of Gd-DTPA in blood
6) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0 Pain Relevance 0.47

General Comments

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