INT27146

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.18
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
uvea 2
nerve 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 36 100.00 Very High Very High Very High
agonist 2 99.36 Very High Very High Very High
qutenza 3 99.24 Very High Very High Very High
trigeminal ganglion 2 97.84 Very High Very High Very High
tetrodotoxin 3 97.56 Very High Very High Very High
Nicotine 7 95.92 Very High Very High Very High
Pain 2 92.16 High High
antagonist 2 87.00 High High
Analgesic 1 82.60 Quite High
Neurotransmitter 2 59.60 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 99.80 Very High Very High Very High
Shock 5 99.20 Very High Very High Very High
Pain 2 92.16 High High
Tendinopathy 2 78.20 Quite High
Colitis 3 77.16 Quite High
Pseudarthrosis 1 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following damage to the Gasserian ganglion a marked decrease of CGRP immunoreactivity was observed in the anterior uvea (control 11.3 +/- 1.6 pmoles/gm; operated 1.4 +/- 0.1 pmoles/gm) confirming the origin of the immunoreactive fibres from trigeminal primary sensory neurons.
Negative_regulation (decrease) of Regulation (immunoreactivity) of CGRP in uvea associated with ganglion cysts and calcitonin gene-related peptide
1) Confidence 0.43 Published 1985 Journal J. Comp. Neurol. Section Abstract Doc Link 2579983 Disease Relevance 0.29 Pain Relevance 0.67
There was nearly complete degeneration of epidermal nerve fibres in the shock wave-treated skin, as indicated by the loss of immunoreactivity for PGP 9.5 or CGRP.
Negative_regulation (loss) of Regulation (immunoreactivity) of CGRP in nerve associated with shock and calcitonin gene-related peptide
2) Confidence 0.43 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11711214 Disease Relevance 0.74 Pain Relevance 0.40
CGRP immunoreactivity was abolished by treatment with capsaicin.
Negative_regulation (abolished) of Regulation (immunoreactivity) of CGRP associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.39 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9083781 Disease Relevance 0 Pain Relevance 0.89
Atropine, doxantrazole, and indomethacin did not block the effects of CGRP or the CGRP(2) agonists.
Negative_regulation (block) of Regulation (effects) of CGRP associated with agonist and calcitonin gene-related peptide
4) Confidence 0.37 Published 2000 Journal FASEB J. Section Abstract Doc Link 10877837 Disease Relevance 0.15 Pain Relevance 0.93

General Comments

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