INT271463

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 23
Disease Relevance 22.25
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Rg9mtd2)
Anatomy Link Frequency
pore 5
brain 4
temporalis 3
anterior 2
posterior 2
Rg9mtd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 328 99.92 Very High Very High Very High
bradykinin 360 97.64 Very High Very High Very High
b2 receptor 295 97.60 Very High Very High Very High
agonist 370 96.68 Very High Very High Very High
isoflurane 23 85.68 High High
anesthesia 95 83.76 Quite High
depression 18 66.80 Quite High
Thalamus 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 1959 100.00 Very High Very High Very High
Cancer 2390 99.80 Very High Very High Very High
Brain Tumor 652 99.74 Very High Very High Very High
Solid Tumor 465 96.08 Very High Very High Very High
Malignant Neoplastic Disease 740 90.96 High High
Depression 18 66.80 Quite High
Toxicity 18 61.84 Quite High
Breast Cancer 36 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For posterior RG-2 gliomas there was a significant percent change in Gd-DTPA AUC with bradykinin B2 receptor agonist infusion (F4,35 = 6.72, p = 0.0004), but no statistically significant tumor volume effect (F1,35 = 3.01, p = 0.0915).
Gene_expression (gliomas) of RG-2 in posterior associated with cancer, agonist, b2 receptor and glioma
1) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.93 Pain Relevance 0.47
On post hoc analysis, in the BK group and Lys-BK group to NS group comparisons, there was no significant change in Gd-DTPA AUC for anterior brain and posterior brain RG-2 gliomas (Figure 7A and 7B).
Gene_expression (gliomas) of RG-2 in brain associated with bradykinin and glioma
2) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.93 Pain Relevance 0.44
For anterior brain RG-2 gliomas, there was a statistically significant increase in the Gd-DTPA AUC with the intravenous infusions of Met-Lys-BK and labradimil.
Gene_expression (gliomas) of RG-2 in anterior associated with bradykinin and glioma
3) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.23 Pain Relevance 0.41
In the labradimil group to NS group comparison, there was a statistically significant percent decrease in the Ktrans of the BBTB for both anterior brain (p = 0.0315) and posterior brain (p = 0.0172) RG-2 gliomas (Figure 4A and 4B).


Gene_expression (gliomas) of RG-2 in anterior associated with glioma
4) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.10 Pain Relevance 0.16
Since Gd-G7 dendrimers were permeable to both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas, but the Gd-G8 dendrimers were not, this establishes the effective physiologic upper limit of pore size in both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas as being approximately 12 nm.
Gene_expression (gliomas) of RG-2 in pore associated with glioma
5) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.84 Pain Relevance 0
The right brain caudate nucleus (orthotopic RG-2 glioma)[28] and left temporalis muscle (ectopic RG-2 glioma) locations were stereotactically inoculated with 105 RG-2 glioma cells in 5 ?
Gene_expression (glioma) of RG-2 in temporalis associated with glioma
6) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.44 Pain Relevance 0.22
In vitro magnetic resonance imaging of RG-2 gliomas
Gene_expression (gliomas) of RG-2 associated with imagery and glioma
7) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.33 Pain Relevance 0.23
The peak Gd concentrations of Gd-G8 dendrimers in ectopic RG-2 gliomas and orthotopic RG-2 gliomas were similar and reflect the peak Gd-G8 dendrimer concentrations within the microvasculature of the respective tumors.
Gene_expression (gliomas) of RG-2 associated with cancer and glioma
8) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.28 Pain Relevance 0
In the case of peripheral RG-2 gliomas, we report here that the physiologic upper limit of pore size in the BTB of ectopic RG-2 gliomas growing in skeletal muscle is equivalent to the upper limit of pore size in the BTB of orthotopic RG-2 gliomas growing in brain tissue, and is also approximately 12 nm.
Gene_expression (gliomas) of RG-2 in skeletal muscle associated with glioma
9) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.80 Pain Relevance 0
Although we found that the physiologic upper limit of pore size in the BTB of brain tumors (orthotopic RG-2 gliomas) as well as peripheral tumors (ectopic RG-2 gliomas) was equivalent, the transvascular extravasation of the permeable particles (i.e.
Gene_expression (gliomas) of RG-2 in brain associated with cancer, glioma and brain tumor
10) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.08 Pain Relevance 0
Physiologic upper limit of pore size within the BTB of orthotopic and ectopic RG-2 gliomas as visualized on Gd concentration maps
Gene_expression (gliomas) of RG-2 in pore associated with glioma
11) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.36 Pain Relevance 0.21
The right brain caudate nucleus (orthotopic RG-2 glioma)[28] and left temporalis muscle (ectopic RG-2 glioma) locations were stereotactically inoculated with 105 RG-2 glioma cells in 5 ?
Gene_expression (glioma) of RG-2 in temporalis associated with glioma
12) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.43 Pain Relevance 0.22
Permeability of the BTB of orthotopic and ectopic RG-2 gliomas to Gd-PAMAM dendrimer generations
Gene_expression (gliomas) of RG-2 associated with glioma
13) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.66 Pain Relevance 0
Using this approach, we found that the physiologic upper limit of pore size in the BTB of brain RG-2 gliomas and peripheral RG-2 gliomas is approximately 12 nm.
Gene_expression (gliomas) of RG-2 in brain associated with glioma
14) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.47 Pain Relevance 0
The right brain caudate nucleus (orthotopic RG-2 glioma)[28] and left temporalis muscle (ectopic RG-2 glioma) locations were stereotactically inoculated with 105 RG-2 glioma cells in 5 ?
Gene_expression (glioma) of RG-2 in temporalis associated with glioma
15) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.44 Pain Relevance 0.19
Since Gd-G7 dendrimers were permeable to both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas, but the Gd-G8 dendrimers were not, this establishes the effective physiologic upper limit of pore size in both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas as being approximately 12 nm.
Gene_expression (gliomas) of RG-2 in pore associated with glioma
16) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.81 Pain Relevance 0
Since Gd-G7 dendrimers were permeable to both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas, but the Gd-G8 dendrimers were not, this establishes the effective physiologic upper limit of pore size in both the BTB of ectopic RG-2 gliomas and orthotopic RG-2 gliomas as being approximately 12 nm.
Gene_expression (gliomas) of RG-2 in pore associated with glioma
17) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.81 Pain Relevance 0
Although we found that the physiologic upper limit of pore size in the BTB of brain tumors (orthotopic RG-2 gliomas) as well as peripheral tumors (ectopic RG-2 gliomas) was equivalent, the transvascular extravasation of the permeable particles (i.e.
Gene_expression (gliomas) of RG-2 in brain associated with cancer, glioma and brain tumor
18) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.01 Pain Relevance 0
The peak Gd concentrations of Gd-G8 dendrimers in ectopic RG-2 gliomas and orthotopic RG-2 gliomas were similar and reflect the peak Gd-G8 dendrimer concentrations within the microvasculature of the respective tumors.
Gene_expression (gliomas) of RG-2 associated with cancer and glioma
19) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.34 Pain Relevance 0
However, these Gd-dendrimer generations extravasated to a greater extent across the BTB of ectopic RG-2 gliomas than the BTB of orthotopic RG-2 gliomas, as Gd-G5, Gd-G6, and Gd-G7 dendrimers achieved higher peak concentrations in the tumor tissue extravascular space of ectopic RG-2 malignant gliomas than in the tumor tissue extravascular space of orthotopic RG-2 malignant gliomas.
Gene_expression (gliomas) of RG-2 associated with cancer and glioma
20) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.34 Pain Relevance 0

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