INT271477

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
macrophages 4
Mmp12 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 92.08 High High
metalloproteinase 4 91.60 High High
Inflammatory response 6 90.16 High High
substance P 22 80.08 Quite High
antagonist 30 77.52 Quite High
Inflammatory mediators 4 16.48 Low Low
chemokine 4 5.00 Very Low Very Low Very Low
c fibre 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 16 98.08 Very High Very High Very High
Disease 4 97.84 Very High Very High Very High
Emphysema 20 95.48 Very High Very High Very High
Pulmonary Disease 52 94.24 High High
INFLAMMATION 54 92.08 High High
Asthma 2 80.92 Quite High
Apoptosis 2 69.52 Quite High
Sprains And Strains 6 58.28 Quite High
Death 4 57.68 Quite High
Pneumonia 14 23.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lower numbers of macrophages and DCs, combined with impaired release of MMP-12, also resulted in an attenuation of CS-induced pulmonary emphysema in NK1-R-/- mice.
Negative_regulation (impaired) of Localization (release) of MMP-12 in macrophages associated with pulmonary emphysema
1) Confidence 0.31 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 1.19 Pain Relevance 0.25
The lower numbers of both macrophages and DCs in CS-exposed NK1-R-/- mice should thus result in a diminished release of MMP-12 in these mice.
Negative_regulation (diminished) of Localization (release) of MMP-12 in macrophages
2) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.52 Pain Relevance 0.18

General Comments

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