INT271488

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 72 92.28 High High
Inflammation 91 91.92 High High
rheumatoid arthritis 53 80.80 Quite High
Arthritis 14 38.04 Quite Low
antagonist 1 36.16 Quite Low
Inflammatory response 1 29.52 Quite Low
Multiple sclerosis 2 19.36 Low Low
tolerance 7 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 72 99.34 Very High Very High Very High
INFLAMMATION 89 91.92 High High
Hypersensitivity 29 91.68 High High
Asthma 104 91.52 High High
Infection 5 87.68 High High
Rheumatoid Arthritis 53 80.80 Quite High
Recurrence 1 79.28 Quite High
Influenza Virus Infection 4 68.16 Quite High
Eosinophilia 8 67.72 Quite High
Diphtheria 12 65.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
reversed the TH1 cell inhibition of TH2 cell-induced AHR [159].
Negative_regulation (reversed) of Negative_regulation (inhibition) of TH2
1) Confidence 0.18 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.54 Pain Relevance 0.14
In our present study, CpG induced the highest IgG2a titers among all M-TCI groups and our results strongly support a skewing of the Th1/Th2 balance towards the Th1 direction, similar to the immune modulatory effect of CpG in mucosal and injection vaccination.
Negative_regulation (support) of Negative_regulation (skewing) of Th2 associated with immunization
2) Confidence 0.16 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.59 Pain Relevance 0.09
Most recently, a placental derived protein (placental protein 14) could be identified that inhibited Th1 immune responses and synergized with IL-4 to promote Th2 immunity by inhibiting the downmodulation of the Th2 specific transcription factor GATA-3 [36].
Negative_regulation (inhibiting) of Negative_regulation (downmodulation) of Th2
3) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 1.24 Pain Relevance 0.44

General Comments

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