INT271522

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 21 88.72 High High
antagonist 14 73.76 Quite High
Hyperalgesia 1 63.12 Quite High
Peripheral nerve injury 1 61.20 Quite High
Central nervous system 15 54.36 Quite High
Hippocampus 1 5.84 Low Low
imagery 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 172 97.44 Very High Very High Very High
Breast Cancer 21 96.48 Very High Very High Very High
Targeted Disruption 2 95.56 Very High Very High Very High
Apoptosis 62 87.20 High High
Adhesions 92 82.44 Quite High
Metastasis 98 73.08 Quite High
Hyperalgesia 1 63.12 Quite High
Nervous System Injury 1 60.32 Quite High
Lymphatic System Cancer 5 52.72 Quite High
Carcinoma 50 51.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with data in Figure 2A, immunoblot analysis of cells cultured on inserts indicated decreased FAK phosphorylation and total protein in control HT29 cells co-cultured in proximity with CXCL12-secreting cells (Figure 2C).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of FAK
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.25 Pain Relevance 0.10
Echistatin has been found to induce a decrease of both auto-phosphorylation and kinase activity of pp125FAK, suggesting inhibitory activity in processes integral to angiogenesis, such as cell growth, survival, and migration (Della et al. 2000).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of pp125FAK
2) Confidence 0.14 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.61 Pain Relevance 0.13
1 integrin after induction of tumorigenesis resulted in impairment of FAK phosphorylation and proliferation consistent with a reliance on anchorage-dependent signaling for tumor growth.
Negative_regulation (impairment) of Phosphorylation (phosphorylation) of FAK associated with cancer
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2689678 Disease Relevance 1.22 Pain Relevance 0.03

General Comments

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