INT271523

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 8.00
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
vessels 6
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 78.64 Quite High
Central nervous system 15 77.44 Quite High
cytokine 4 33.20 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 236 99.68 Very High Very High Very High
Neointima 36 99.60 Very High Very High Very High
Metastasis 74 99.32 Very High Very High Very High
Cancer 399 99.20 Very High Very High Very High
Glioblastoma 51 96.80 Very High Very High Very High
Malignant Neoplastic Disease 25 96.28 Very High Very High Very High
Adhesions 142 96.08 Very High Very High Very High
Brain Tumor 12 89.44 High High
Anaplastic Astrocytoma 5 87.56 High High
Adenocarcinoma 5 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors mediating expression of FAK and integrins 5?
Positive_regulation (mediating) of Gene_expression (expression) of FAK
1) Confidence 0.65 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.60 Pain Relevance 0.04
The immunostaining of FAK and FAK(pY397) in serial sections revealed that increased expression of FAK was accompanied by an increase of expression of FAK(pY397) Fig. 1d–e).Fig. 1Confocal micrographs of FAK and FAK(pY397) immunostaining in normal (NV), control (only ligation) (CLV), and AV-shunt (AV-S) collateral vessels. a–d: FAK; e: FAK(pY397). a: NV; b: CLV, c, d and e: AV-S.
Positive_regulation (increased) of Gene_expression (expression) of FAK in vessels
2) Confidence 0.65 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
FAK is overexpressed in invasive and metastatic tumors [16], and the FAK gene is also amplified in many types of tumors [17] suggesting a role for FAK in adhesion or survival in tumor cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of FAK associated with cancer, adhesions and metastasis
3) Confidence 0.65 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.65 Pain Relevance 0
However, the causal role of FAK in tumor development combined with reports that increased FAK expression is associated with poor clinical outcome [8,9], indicate that FAK might be a useful therapeutic target [7,10].
Positive_regulation (increased) of Gene_expression (expression) of FAK associated with cancer
4) Confidence 0.65 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.60 Pain Relevance 0
The immunostaining of FAK and FAK(pY397) in serial sections revealed that increased expression of FAK was accompanied by an increase of expression of FAK(pY397) Fig. 1d–e).Fig. 1Confocal micrographs of FAK and FAK(pY397) immunostaining in normal (NV), control (only ligation) (CLV), and AV-shunt (AV-S) collateral vessels. a–d: FAK; e: FAK(pY397). a: NV; b: CLV, c, d and e: AV-S.
Positive_regulation (increase) of Gene_expression (expression) of FAK in vessels
5) Confidence 0.47 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
The immunostaining of FAK and FAK(pY397) in serial sections revealed that increased expression of FAK was accompanied by an increase of expression of FAK(pY397) Fig. 1d–e).Fig. 1Confocal micrographs of FAK and FAK(pY397) immunostaining in normal (NV), control (only ligation) (CLV), and AV-shunt (AV-S) collateral vessels. a–d: FAK; e: FAK(pY397). a: NV; b: CLV, c, d and e: AV-S.
Positive_regulation (increase) of Gene_expression (expression) of FAK in vessels
6) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
The causal role of FAK in tumor development combined with reports that increased FAK expression is associated with poor clinical outcome [8,9] indicates that FAK might be a useful therapeutic target [7,10].
Positive_regulation (increased) of Gene_expression (expression) of FAK associated with cancer
7) Confidence 0.44 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.04 Pain Relevance 0
We found an elevated expression of FAK in the glioma cells, which was highly downregulated by hUCBSC in the co-cultures.
Positive_regulation (elevated) of Gene_expression (expression) of FAK associated with glioma
8) Confidence 0.44 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.86 Pain Relevance 0
Furthermore, the ability of tumor cells to migrate is demonstrated to be associated with increased FAK expression.
Positive_regulation (increased) of Gene_expression (expression) of FAK associated with cancer
9) Confidence 0.44 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.85 Pain Relevance 0
ESb cells were highly immunoreactive for pFAK-Y397 confirming integrin-mediated anchorage-dependent signaling (Fig. 8D).
Positive_regulation (confirming) of Gene_expression (immunoreactive) of pFAK-Y397
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2689678 Disease Relevance 0.41 Pain Relevance 0.04

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