INT271539

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Chl1) extracellular region (Chl1) cell adhesion (Chl1)
proteinaceous extracellular matrix (Chl1) plasma membrane (Chl1)
Anatomy Link Frequency
cerebellar cortex 1
synapse 1
Chl1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 60 97.20 Very High Very High Very High
Pyramidal cell 6 80.64 Quite High
gABA 12 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
interneuron 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
unmyelinated 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 33 79.40 Quite High
Adhesions 24 65.20 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
General Immunology 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not clear whether these are due to a direct effect of CHL1 deficiency in BG or an indirect consequence of their disrupted association with stellate axons.


Negative_regulation (deficiency) of CHL1
1) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.08
We suggest that CHL1 deficiency results in dissociation of stellate axons from their normal BG fiber “tracks,” aberrant axon orientation and trajectory, which contribute to subsequent deficiency in synapse formation and stability.
Negative_regulation (deficiency) of CHL1 in synapse
2) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.07 Pain Relevance 0.13
In the adult cerebellar cortex (>P40), we found a profound reduction of GAD65 labeling in CHL1?
Negative_regulation (reduction) of CHL1 in cerebellar cortex
3) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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