INT271545

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2008
Negated 4
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 1.34
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Chl1) extracellular region (Chl1) cell adhesion (Chl1)
proteinaceous extracellular matrix (Chl1) plasma membrane (Chl1)
Anatomy Link Frequency
neurons 3
stellate cells 2
parallel fibers 2
dendrites 1
molecular layer 1
Chl1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 360 93.52 High High
Hippocampus 18 80.28 Quite High
unmyelinated 18 65.44 Quite High
Pyramidal cell 36 47.04 Quite Low
gABA 72 25.00 Low Low
ketamine 18 5.00 Very Low Very Low Very Low
anesthesia 18 5.00 Very Low Very Low Very Low
interneuron 18 5.00 Very Low Very Low Very Low
Somatostatin 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 198 95.28 Very High Very High Very High
Frailty 36 95.12 Very High Very High Very High
Sprains And Strains 36 93.04 High High
Adhesions 144 78.36 Quite High
Increased Venous Pressure Under Development 18 44.72 Quite Low
Body Weight 36 5.00 Very Low Very Low Very Low
General Immunology 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHL1 was subsequently also detected along the lateral appendages during the second and third week (P14–20, Figure 4C1 and 4E).
Gene_expression (detected) of CHL1 in lateral appendages
1) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
Like other members of the L1CAM [20], CHL1 is expressed in both neurons and glia [31,53].
Gene_expression (expressed) of CHL1 in neurons
2) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.08
At P14, P20, and P40 in GFAP-Cre::CHL1flx/flx mice, CHL1 expression was undectable along BG fibers but was clearly present in stellate cells (Figure 8A–8C).
Gene_expression (expression) of CHL1 in stellate cells
3) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.34 Pain Relevance 0
In addition, Purkinje dendrites and their glutamatergic innervation by climbing fibers and parallel fibers also appeared intact, even though CHL1 is known to be expressed in granule cells and parallel fibers [31,53].
Gene_expression (expressed) of CHL1 in climbing fibers
4) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
We further characterized the postnatal developmental expression of CHL1.
Gene_expression (expression) of CHL1
5) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
Besides BG, CHL1 is also expressed in other cell types, such as stellate cells, granule cells, and their parallel fibers in the developing cerebellum [31].
Gene_expression (expressed) of CHL1 in cerebellum
6) Confidence 0.77 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.26 Pain Relevance 0
Although there is evidence that CHL1 promotes and inhibits neurite outgrowth in vitro through both heterophilic and homophilic interactions, respectively [54,55], and may regulate hippocampal axon projection and organization [56,57], the cellular interactions involved and the logic of CHL1?
Gene_expression (promotes) of CHL1 in neurite
7) Confidence 0.67 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.07
In particular, CHL1 (Close Homologue of L1) is prominently expressed on BG fibers during the development of stellate axons and their innervation.
Gene_expression (expressed) of CHL1
8) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.08 Pain Relevance 0.04
Lower levels of CHL1 expression in the ML remained in adulthood (in 1-y-old mice, unpublished data).


Gene_expression (expression) of CHL1
9) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.07 Pain Relevance 0.12
CHL1 expression subsequently diminished in the BG fibers and became more diffuse, yet prominent, in the molecular layer (Figure 4D1).
Gene_expression (expression) of CHL1 in molecular layer
10) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0
In the absence of CHL1, stellate axons deviate from BG fibers and show aberrant branching and orientation.
Neg (absence) Gene_expression (absence) of CHL1
11) Confidence 0.60 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2689695 Disease Relevance 0.16 Pain Relevance 0.04
These results suggest that CHL1 expression in BG contributes to the development of stellate cell synaptic innervation in the ML.
Gene_expression (expression) of CHL1 in stellate cell
12) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.29 Pain Relevance 0
We cannot ascertain whether CHL1 is also expressed in the fine BG fiber processes (due to the presence of CHL1 in parallel fibers and possibly other neural elements in the ML).
Gene_expression (expressed) of CHL1 in parallel fibers
13) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0
In addition, CHL1 is expressed in stellate cells, but not in Purkinje neurons [31].
Neg (not) Gene_expression (expressed) of CHL1 in neurons
14) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0
The well-defined architecture and connectivity in cerebellar cortex present an advantage in defining the cellular and subcellular expression of CHL1 and in dissecting its role in axonal and synapse development.
Gene_expression (expression) of CHL1 in synapse
15) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.06
In situ hybridization indicates that CHL1 is also expressed in stellate interneurons and granule cells at P14, but not in mature Purkinje neurons [31].
Neg (not) Gene_expression (expressed) of CHL1 in neurons
16) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.06
Together, these ultrastructural results suggest that in the absence of CHL1, aberrantly organized and oriented stellate axons can still manage to contact Purkinje dendrites and form synapses, but at significantly reduced efficiency and density.
Neg (absence) Gene_expression (absence) of CHL1 in dendrites
17) Confidence 0.60 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.13 Pain Relevance 0
In addition, Purkinje dendrites and their glutamatergic innervation by climbing fibers and parallel fibers also appeared intact, even though CHL1 is known to be expressed in granule cells and parallel fibers [31,53].
Gene_expression (expressed) of CHL1 in parallel fibers
18) Confidence 0.26 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03

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