INT271547

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.33
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Chl1) extracellular region (Chl1) cell adhesion (Chl1)
proteinaceous extracellular matrix (Chl1) plasma membrane (Chl1)
Anatomy Link Frequency
dendrites 2
stellate cells 1
Purkinje cell 1
synapse 1
Chl1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 120 98.12 Very High Very High Very High
unmyelinated 6 75.76 Quite High
gABA 24 25.00 Low Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
interneuron 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 66 85.64 High High
Frailty 12 72.72 Quite High
Adhesions 48 54.36 Quite High
Sprains And Strains 12 24.16 Low Low
Body Weight 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
General Immunology 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The L1 family immunoglobulin protein Close Homologue of L1 (CHL1) is localized to apical BG fibers and stellate cells during the development of stellate axon arbors.
Localization (localized) of CHL1 in stellate cells
1) Confidence 0.80 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2689695 Disease Relevance 0.16 Pain Relevance 0.04
Interestingly, a recent study shows that CHL1 is localized at presynaptic terminals of glutamatergic and GABAergic axons in dissociated hippocampal cultures [58]; CHL1 appears to be targeted to synaptic vesicles by endocytosis in response to synapse activation and regulates the uncoating of clathrin-coated synaptic vesicles [58].
Localization (localized) of CHL1 in synapse associated with gabaergic
2) Confidence 0.80 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.08
It is tempting to speculate that another form of ankyrin in BG cells may organize CHL1 subcellular localization.
Localization (localization) of CHL1
3) Confidence 0.80 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.11 Pain Relevance 0
Importantly, along the polarized BG cells, CHL1 was mainly localized to the apical radial fibers and processes, but not to the basal lamellae that extend towards Purkinje cell AIS (Figure 4F).
Neg (not) Localization (localized) of CHL1 in Purkinje cell
4) Confidence 0.75 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
Indeed, CHL1 closely colocalized with GFAP (Figure 4E), but not the Purkinje dendrite marker calbindin (Figure S2F).
Neg (not) Localization (colocalized) of CHL1 in dendrite
5) Confidence 0.75 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.04
Finally, CHL1 might also be localized to stellate dendrites, which are innervated by other stellate axons.
Localization (localized) of CHL1 in dendrites
6) Confidence 0.70 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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