INT271571

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.65
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MIOX)
Anatomy Link Frequency
brain 1
epithelial cell 1
white matter 1
MIOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 99.36 Very High Very High Very High
Inflammation 24 97.76 Very High Very High Very High
corticosteroid 20 96.12 Very High Very High Very High
agonist 2 86.24 High High
glial activation 2 68.28 Quite High
Neurobehavioral 7 54.12 Quite High
Central nervous system 23 45.84 Quite Low
Inflammatory response 4 37.12 Quite Low
rheumatoid arthritis 1 34.56 Quite Low
psoriasis 1 28.64 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 99.36 Very High Very High Very High
Gliosis 2 99.36 Very High Very High Very High
Hepatitis C Virus Infection 189 97.92 Very High Very High Very High
Sprains And Strains 138 94.16 High High
Asthma 48 92.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 77 89.92 High High
Infection 60 81.52 Quite High
Dyspnea 3 77.36 Quite High
Respiratory Sounds 2 75.72 Quite High
Disease 12 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data showed that core protein from HCV genotype 1b triggered in vitro and in vivo activation of microglia and astrocytes, which is consistent with a recent magnetic resonance spectroscopy study that revealed an increased level of myo-inositol, a hallmark of gliosis, in frontal white matter of HCV-infected individuals [61].
Positive_regulation (increased) of myo-inositol in white matter associated with gliosis and hepatitis c virus infection
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.78 Pain Relevance 0.06
Our results with real-time PCR showed that these ITR genes are differentially expressed in response to myo-inositol induction.
Positive_regulation (induction) of myo-inositol
2) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.27 Pain Relevance 0
The importance of myo-inositol for fungal mating and the facts that Cryptococcus can utilize myo-inositol as a sole carbon source and that the human brain contains a high concentration of myo-inositol all indicate that myo-inositol is important for this fungus.
Positive_regulation (important) of myo-inositol in brain
3) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.06 Pain Relevance 0
We have previously demonstrated that several miRNAs are upregulated in response to inflammatory stimuli in mouse models of inflammation and in human epithelial cell lines [27], [28].
Positive_regulation (upregulated) of miRNAs in epithelial cell associated with inflammation and inflammatory stimuli
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 1.55 Pain Relevance 0.34

General Comments

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