INT271573

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SCPEP1) peptidase activity (SCPEP1) extracellular region (SCPEP1)
SCPEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 44 70.04 Quite High
corticosteroid 21 64.64 Quite High
agonist 45 54.20 Quite High
psoriasis 1 13.92 Low Low
dexamethasone 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 171 94.92 High High
Disease 39 89.60 High High
Papillomavirus Infection 1 83.96 Quite High
INFLAMMATION 50 70.04 Quite High
Malignant Neoplastic Disease 12 62.64 Quite High
Asthma 48 61.96 Quite High
Coronary Heart Disease 3 61.36 Quite High
Hematologic Neoplasms 39 60.56 Quite High
Syndrome 4 58.04 Quite High
Polycystic Kidney Disease 6 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two chaperone proteins, HSCP-70 and HSP70-1, bind to tuberin.
HSCP Binding (bind) of
1) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.45 Pain Relevance 0
Finally, the mature miRNA is loaded onto the Argonaute (Ago) protein and incorporated into the ribonucleoprotein complex, RISC (RNA induced silencing complex) [244], which directs the miRNA to its target mRNA.
RISC Binding (directs) of
2) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.36 Pain Relevance 0.03
One strand of the miRNA, referred to as the mature miRNA (the other strand miRNA* is generally degraded), is incorporated into a large ribonucleoprotein (RNP) complex called the miRNA-induced silencing complex (miRISC), where it binds to its target mRNA [5], [6].
miRISC Binding (binds) of
3) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.40 Pain Relevance 0.10

General Comments

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