INT271575

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 25
Total Number 31
Disease Relevance 11.26
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MIOX)
Anatomy Link Frequency
lungs 3
alveolar macrophages 2
macrophages 1
brain 1
fibroblasts 1
MIOX (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 560 99.06 Very High Very High Very High
agonist 56 98.66 Very High Very High Very High
Inflammatory response 56 98.48 Very High Very High Very High
dexamethasone 28 96.92 Very High Very High Very High
rheumatoid arthritis 28 95.92 Very High Very High Very High
Inflammation 560 94.52 High High
chemokine 28 93.08 High High
cytokine 28 92.48 High High
psoriasis 28 90.00 High High
iatrogenic 3 49.08 Quite Low
Disease Link Frequency Relevance Heat
Asthma 1344 99.84 Very High Very High Very High
Infection 39 99.56 Very High Very High Very High
INFLAMMATION 644 98.12 Very High Very High Very High
Cancer 115 97.68 Very High Very High Very High
Occupational Lung Diseases 196 96.92 Very High Very High Very High
Solid Tumor 28 96.92 Very High Very High Very High
Meningitis 12 96.68 Very High Very High Very High
Rheumatoid Arthritis 28 95.92 Very High Very High Very High
Cryptococcal Meningitis 15 92.60 High High
Psoriasis 28 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The INO1 gene and inositol monophosphatase were found to be abundant in a SAGE library generated from RNAs isolated during brain infection, suggesting that the myo-inositol internal synthesis pathway is functional and that inositol could be important for the development of meningitis (34).
Gene_expression (synthesis) of myo-inositol in brain associated with meningitis and infection
1) Confidence 0.06 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.36 Pain Relevance 0
We found that free myo-inositol exists on several living plant surfaces, and the concentration on Eucalyptus is much higher than on Arabidopsis, which could have significant implications for how this human pathogen completes its sexual cycle in nature, since Eucalyptus is the major environmental niche for C. gattii (26).
Gene_expression (exists) of myo-inositol
2) Confidence 0.06 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.12 Pain Relevance 0
Because myo-inositol is the main carbon source in MS medium, we replaced myo-inositol with other carbon sources, including glucose, sucrose, galactose, and glycerol.
Gene_expression (source) of myo-inositol
3) Confidence 0.06 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0 Pain Relevance 0
The authors also appreciate that despite the identification of >700 human miRNAs, we were only able to analysis the expression of 227 miRNAs.
Gene_expression (expression) of miRNAs
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.28 Pain Relevance 0.16
Alveolar macrophages possessed the highest number of highly expressed miRNAs than the other cell types and included miR-92, miR-223, miR-191, miR-30a-5p, miR-320, miR-342, miR-146b and miR-142-3p.
Gene_expression (expressed) of miRNAs in Alveolar macrophages
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0 Pain Relevance 0
The expression of 227 miRNAs was analysed by RT-PCR from each individual biopsy.
Spec (analysed) Gene_expression (expression) of miRNAs
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 1.10 Pain Relevance 0.11
Furthermore, we have analysed the expression of miRNAs from individual cell populations from the airway and lung.
Spec (analysed) Gene_expression (expression) of miRNAs in lung
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690402 Disease Relevance 0.68 Pain Relevance 0.27
These findings gave an indication as to which cell types contributed the most to the overall expression level of an individual miRNA within the airways, even though all 26 miRNAs were expressed 10-fold or more higher than average.
Gene_expression (expressed) of miRNAs
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.28 Pain Relevance 0.07
In order to determine the expression of miRNAs in isolated cell types, qRT-PCR was performed on various cell types from the airways and lungs.
Spec (determine) Gene_expression (expression) of miRNAs in lungs
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0 Pain Relevance 0
Expression profiling of human airway biopsies revealed several highly expressed miRNAs, including miR-92, miR-200c, miR-26a, miR-16, let-7b, miR-125a and miR-125b, which together comprised 55.5% of the total miRNA species analysed.
Gene_expression (expressed) of miRNAs
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.42 Pain Relevance 0.30
Three miRNAs, miR-375, miR-449 and miR-200c were specifically expressed only in the airway samples.
Gene_expression (expressed) of miRNAs
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0 Pain Relevance 0
Of the 227 miRNAs analysed no miRNAs were differentially expressed in asthmatic samples compared to healthy.
Neg (no) Gene_expression (expressed) of miRNAs associated with asthma
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.80 Pain Relevance 0.13
We found no significant difference in the expression of 227 miRNAs in the airway biopsies obtained from normal and mild asthmatic patients.
Gene_expression (expression) of miRNAs associated with asthma
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690402 Disease Relevance 0.66 Pain Relevance 0.26
The expression of miRNAs in epithelial cells was similar to that in whole lung and included miR-125a, miR-30b/c/d, miR-20d, miR-93 and miR-26b, although some of the miRNAs were also significantly expressed in macrophages and fibroblasts (e.g. miR-30c).
Gene_expression (expression) of miRNAs in macrophages
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0 Pain Relevance 0
Indeed, this conclusion is demonstrated in the supplemental Tables where we failed to observe the expression of the most recently identified miRNAs i.e. miR-500 upwards.
Gene_expression (expression) of miRNAs
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.36 Pain Relevance 0.15
Despite some of the highly expressed miRNAs containing NF-?
Gene_expression (expressed) of miRNAs
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.57 Pain Relevance 0.42
Two miRNAs, miR-375 and miR-449 were specific only to airway samples, indicating that these miRNAs are expressed in a cell type that is explicit the airways.
Gene_expression (expressed) of miRNAs
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.24 Pain Relevance 0.13
2 agonists and corticosteroids by these patients may also interfere with the expression of miRNAs that may be involved in the pathophysiology of asthma; however, we examined asthmatics who have never received corticosteroid therapy for their asthma.
Gene_expression (expression) of miRNAs associated with asthma, corticosteroid, agonist and occupational lung diseases
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.29 Pain Relevance 0.15
These two miRNAs have previously been shown to be specifically expressed in myeloid and lymphoid cell lineages [35] and may function as regulators of the innate immune system [27].
Gene_expression (expressed) of miRNAs in immune system
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.35 Pain Relevance 0.16
For example, several MAP kinases were predicted to be targets, suggesting that these highly expressed miRNAs may be able to inhibit signalling molecules involved in the inflammatory response.
Gene_expression (expressed) of miRNAs associated with inflammatory response
20) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 0.67 Pain Relevance 0.18

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