INT27158

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Context Info
Confidence 0.13
First Reported 1984
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.84
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
THAL 2
neurons 2
gill 2
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
Dopamine 7 100.00 Very High Very High Very High
Immobilon 2 99.98 Very High Very High Very High
opiate 9 98.76 Very High Very High Very High
addiction 3 98.72 Very High Very High Very High
tolerance 5 97.92 Very High Very High Very High
Antinociceptive 2 97.52 Very High Very High Very High
Clonidine 10 96.76 Very High Very High Very High
action potential duration 4 95.88 Very High Very High Very High
opioid receptor 4 93.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 99.68 Very High Very High Very High
Cancer 6 95.28 Very High Very High Very High
Vibrio Infection 6 94.24 High High
Drug Dependence 1 89.60 High High
Targeted Disruption 1 80.40 Quite High
Pain 2 64.84 Quite High
Sepsis 2 5.00 Very Low Very Low Very Low
Natriuresis 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is shown that carnosine inhibits the activation of soluble guanylate cyclase by sodium nitroprusside and a derivative of furoxan--1,2,5-oxadiazolo-trioxide (an NO donor).
Negative_regulation (inhibits) of Positive_regulation (activation) of cyclase
1) Confidence 0.13 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0 Pain Relevance 0
However, the deletion of beta-arrestin-2 does not prevent the chronic morphine-induced up-regulation of adenylyl cyclase activity, a cellular marker of dependence, and the mutant mice still become physically dependent on the drug.
Negative_regulation (prevent) of Positive_regulation (up-regulation) of cyclase associated with addiction and morphine
2) Confidence 0.04 Published 2000 Journal Nature Section Abstract Doc Link 11130073 Disease Relevance 0.29 Pain Relevance 1.20
This effect of forskolin was blocked by incubation of the neurons in 1 mM 2',5'-dideoxyadenosine, an inhibitor of forskolin-induced activation of cyclase in other cells.
Negative_regulation (inhibitor) of Positive_regulation (activation) of cyclase in neurons
3) Confidence 0.04 Published 1985 Journal Pflugers Arch. Section Abstract Doc Link 2580271 Disease Relevance 0.09 Pain Relevance 0.34
Etorphine reduced the dopamine stimulation of cyclase in the ganglion but not in the gill.
Negative_regulation (reduced) of Positive_regulation (stimulation) of cyclase in gill associated with ganglion cysts, dopamine and immobilon
4) Confidence 0.02 Published 1986 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3013405 Disease Relevance 0.57 Pain Relevance 0.99
Exogenous NO (10(-6)-10(-3) M) evoked relaxations which were unaffected by L-NO-Arg. 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ, 5 x 10(-6) M), an inhibitor of guanylate cyclase activation by NO, reduced the relaxations in response to electrical stimulation and exogenous NO.
Negative_regulation (inhibitor) of Positive_regulation (activation) of cyclase
5) Confidence 0.00 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698209 Disease Relevance 0 Pain Relevance 0.08
In conclusion, alpha(2)-receptor stimulation decreases THAL J(Cl) by increasing NO release and stimulating guanylate cyclase.
Negative_regulation (decreases) of Positive_regulation (stimulating) of cyclase in THAL
6) Confidence 0.00 Published 2001 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 11553515 Disease Relevance 0 Pain Relevance 0.68
Nonhydrolyzable analogs of GTP inhibited toxin-stimulated cyclase activity in the absence of an opiate.
Negative_regulation (inhibited) of Positive_regulation (stimulated) of cyclase associated with opiate
7) Confidence 0.00 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092035 Disease Relevance 0.90 Pain Relevance 0.96

General Comments

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