INT271587

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.15
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfrl) molecular_function (Pdgfrl) cellular_component (Pdgfrl)
biological_process (Pdgfrl)
Anatomy Link Frequency
nerve 3
neurons 1
Pdgfrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 30 98.28 Very High Very High Very High
Dorsal horn 114 98.24 Very High Very High Very High
intrathecal 84 96.40 Very High Very High Very High
Brush evoked pain 120 90.36 High High
withdrawal 42 86.88 High High
Spinal cord 66 85.92 High High
Stimulus evoked pain 12 85.40 High High
Neuropathic pain 90 83.40 Quite High
Dorsal horn neuron 48 82.04 Quite High
cerebral cortex 6 82.00 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 102 99.76 Very High Very High Very High
Neuropathic Pain 222 90.36 High High
Hypersensitivity 12 85.40 High High
Pain 54 84.72 Quite High
Hyperalgesia 6 77.92 Quite High
Paralysis 12 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How PDGFR activity is enhanced remains unclear, but we examined the time course for changes in the expression levels of PDGFR mRNAs after nerve injury and found no significant change during the period from 1 day to 14 days post-nerve injury (Figure 5D).
Positive_regulation (enhanced) of PDGFR in nerve associated with nervous system injury
1) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.81 Pain Relevance 0.60
These results indicate that activation of PDGFR?
Positive_regulation (activation) of PDGFR
2) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.17 Pain Relevance 0.39
It is thus possible that the enhanced PDGFR activity might be due to an increase in the level of endogenous PDGF within the dorsal horn after nerve injury, as suggested by a previous study [24].
Positive_regulation (increase) of PDGFR in nerve associated with nervous system injury and dorsal horn
3) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.82 Pain Relevance 0.59
We used the PDGF-BB isoform in all experiments in this study because PDGF-B chain expression is induced after peripheral nerve injury [25], neurons throughout the CNS contain the PDGF-B chain [26], and the PDGF-B chain activates both PDGFR?
Positive_regulation (activates) of PDGFR in neurons associated with nervous system injury and peripheral nerve injury
4) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.83 Pain Relevance 0.91
In the present study, by showing that acute PDGF stimulation in vivo in adult rats induced PDGFR?
Positive_regulation (induced) of PDGFR
5) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.71 Pain Relevance 0.57
How PDGFR activity is enhanced remains unclear, but we examined the time course for changes in the expression levels of PDGFR mRNAs after nerve injury and found no significant change during the period from 1 day to 14 days post-nerve injury (Figure 5D).
Spec (examined) Positive_regulation (changes) of PDGFR in nerve associated with nervous system injury
6) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.80 Pain Relevance 0.58

General Comments

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