INT271592

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfrl) molecular_function (Pdgfrl) cellular_component (Pdgfrl)
biological_process (Pdgfrl)
Anatomy Link Frequency
peripheral nerve 1
Pdgfrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 14 99.24 Very High Very High Very High
Dorsal horn neuron 8 98.52 Very High Very High Very High
Thermal hyperalgesia 1 97.28 Very High Very High Very High
Brush evoked pain 20 96.28 Very High Very High Very High
Peripheral nerve injury 5 95.32 Very High Very High Very High
Neuropathic pain 15 83.28 Quite High
Stimulus evoked pain 2 79.68 Quite High
Dorsal horn 19 58.88 Quite High
Pain 7 52.04 Quite High
hyperexcitability 1 46.00 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 1 97.28 Very High Very High Very High
Neuropathic Pain 37 96.28 Very High Very High Very High
Nervous System Injury 17 94.88 High High
Pain 9 79.68 Quite High
Hypersensitivity 2 79.28 Quite High
Paralysis 2 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study has shown that PDGF is expressed in dorsal horn neurons in adult mice, and that intrathecal administration of either a selective inhibitor of PDGFR phosphorylation or an antibody trapping endogenous PDGF suppresses thermal hyperalgesia and tactile allodynia after peripheral nerve injury [24].
Negative_regulation (inhibitor) of PDGFR in peripheral nerve associated with brush evoked pain, nervous system injury, thermal hyperalgesia, dorsal horn neuron, peripheral nerve injury and intrathecal
1) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.82 Pain Relevance 0.90

General Comments

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