INT271599

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.55
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
peripheral nerve 1
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 6 99.52 Very High Very High Very High
Thermal hyperalgesia 3 99.52 Very High Very High Very High
intrathecal 42 98.86 Very High Very High Very High
Brush evoked pain 60 98.52 Very High Very High Very High
Dorsal horn neuron 24 98.14 Very High Very High Very High
Peripheral nerve injury 15 97.56 Very High Very High Very High
withdrawal 21 96.12 Very High Very High Very High
spinal dorsal horn 6 94.16 High High
Neuropathic pain 45 87.76 High High
Stimulus evoked pain 6 86.36 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 111 99.52 Very High Very High Very High
Hyperalgesia 3 99.52 Very High Very High Very High
Nervous System Injury 51 97.12 Very High Very High Very High
Hypersensitivity 6 86.36 High High
Pain 27 85.68 High High
Injury 3 51.20 Quite High
Paralysis 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following PDGF administration, the immunofluorescence for phosphorylated PDGF ?
Phosphorylation (phosphorylated) of PDGF
1) Confidence 0.11 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2690582 Disease Relevance 0.95 Pain Relevance 1.02
In addition, we also tested the effect of AG17, a selective inhibitor for PDGFR phosphorylation, on PDGF-BB-induced allodynia.
Phosphorylation (phosphorylation) of PDGF associated with allodynia
2) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.76 Pain Relevance 0.87
A recent study has shown that PDGF is expressed in dorsal horn neurons in adult mice, and that intrathecal administration of either a selective inhibitor of PDGFR phosphorylation or an antibody trapping endogenous PDGF suppresses thermal hyperalgesia and tactile allodynia after peripheral nerve injury [24].
Phosphorylation (phosphorylation) of PDGF in peripheral nerve associated with brush evoked pain, nervous system injury, thermal hyperalgesia, dorsal horn neuron, peripheral nerve injury and intrathecal
3) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.85 Pain Relevance 0.92

General Comments

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