INT271625

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
cleavage 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 88 97.00 Very High Very High Very High
depression 88 79.12 Quite High
long-term potentiation 88 78.80 Quite High
nMDA receptor antagonist 16 9.76 Low Low
Hippocampus 22 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 88 79.12 Quite High
Drug Induced Neurotoxicity 16 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Kernicterus 14 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Jaundice 8 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Newborn Jaundice 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this premise, we first used calpain-mediated spectrin and NR2B subunit cleavage as markers for calpain activation.
Protein_catabolism (cleavage) of NR2B in cleavage
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.14 Pain Relevance 0.30
Western blot analysis found that UCB (10 ┬ÁM) treatment significantly induced a time-dependent increase in spectrin and NR2B subunit cleavage compared with control slices (Figure 9A).
Protein_catabolism (cleavage) of NR2B in cleavage
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.12 Pain Relevance 0.27

General Comments

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