INT271628

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
hippocampus 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 13 99.96 Very High Very High Very High
Spinal cord 2 87.84 High High
Glutamate receptor 27 81.68 Quite High
long-term potentiation 44 80.00 Quite High
nMDA receptor 55 74.08 Quite High
Dorsal horn 1 70.00 Quite High
depression 44 64.80 Quite High
Neurotransmitter 2 52.60 Quite High
Glutamate 20 51.00 Quite High
nMDA receptor antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 87 99.84 Very High Very High Very High
Cognitive Disorder 5 85.84 High High
Obesity 1 82.36 Quite High
Depression 44 64.80 Quite High
Ganglion Cysts 5 56.96 Quite High
Retinal Diseases 1 56.08 Quite High
Glaucoma 1 54.00 Quite High
Retina Disease 1 52.96 Quite High
Diabetic Retinopathy 9 35.36 Quite Low
Blindness 2 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 10A–D, both leupeptin (100 µM) and calpeptin (100 µM) completely prevented UCB-induced down-regulation of NR2A and NR2B subunit proteins.
Negative_regulation (prevented) of Regulation (regulation) of NR2A
1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.06 Pain Relevance 0.07
In the hippocampus, immunoreactivity for NR2A and NR2B subunits are reduced in diabetic rats.
Negative_regulation (reduced) of Regulation (immunoreactivity) of NR2A in hippocampus associated with diabetes mellitus and hippocampus
2) Confidence 0.26 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.99 Pain Relevance 0.40

General Comments

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