INT271635

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
GRIN1 (Homo sapiens)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 44 100.00 Very High Very High Very High
depression 44 100.00 Very High Very High Very High
nMDA receptor 44 100.00 Very High Very High Very High
Hippocampus 11 97.80 Very High Very High Very High
cytokine 5 91.04 High High
Inflammation 6 90.64 High High
nMDA receptor antagonist 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 44 100.00 Very High Very High Very High
INFLAMMATION 7 90.64 High High
Drug Induced Neurotoxicity 8 67.68 Quite High
Kernicterus 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Jaundice 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Newborn Jaundice 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of NMDA receptors blocks LTP and LTD induction, although recent studies using pharmacological NMDA receptor subtype blockade approach has proposed that LTP induction is specifically dependent on activation of NR2A-containing receptors and LTD requires activation of NR2B-containg receptors [39], [40].
Negative_regulation (Inhibition) of NMDA Negative_regulation (blocks) of Positive_regulation (induction) of LTP associated with depression, nmda receptor and long-term potentiation
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.65 Pain Relevance 0.93

General Comments

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