INT27170

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.88
Pain Relevance 7.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 2
heart 1
hippocampus 1
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 97 100.00 Very High Very High Very High
monoamine 88 100.00 Very High Very High Very High
Serotonin 25 100.00 Very High Very High Very High
fluoxetine 18 100.00 Very High Very High Very High
antagonist 14 100.00 Very High Very High Very High
Desipramine 11 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
Norepinephrine uptake inhibitor 1 99.66 Very High Very High Very High
Triptan 3 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 4 98.96 Very High Very High Very High
Depression 20 98.92 Very High Very High Very High
Drug Dependence 7 98.92 Very High Very High Very High
Disease 13 98.64 Very High Very High Very High
Migraine Without Aura 3 98.32 Very High Very High Very High
Cv General 2 Under Development 1 98.22 Very High Very High Very High
Myocardial Infarction 2 97.74 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.44 Very High Very High Very High
Headache 12 95.52 Very High Very High Very High
Headache Disorders 3 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDMA (ecstasy) produced a preferential inhibition of MAO-A (IC50 = 44 mumol/L), which should increase extracellular 5-HT.
Gene_expression (produced) of MAO
1) Confidence 0.67 Published 1994 Journal Neuropsychopharmacology Section Abstract Doc Link 7945733 Disease Relevance 0 Pain Relevance 0.32
Neither selective MAO-A or -B inhibition with clorgyline or deprenyl, respectively, nor inhibition of serotonin reuptake with fluoxetine prior to reserpine produced the serotonin behavioral syndrome.
Gene_expression (produced) of MAO associated with syndrome, serotonin and fluoxetine
2) Confidence 0.67 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2580723 Disease Relevance 0.36 Pain Relevance 0.60
The protein expression and the activity levels of monoamine oxidase A (MAOA), a critical enzyme for the degradation of NE, were decreased in the hippocampus of SPORTS rats to increase extracellular NE level.
Gene_expression (expression) of monoamine oxidase in hippocampus associated with hippocampus and monoamine
3) Confidence 0.67 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16421512 Disease Relevance 0 Pain Relevance 0.61
Acute high doses of clorgyline produce a rapid inhibition of monoamine oxidase type A (MAO A) in the rat brain, together with an increase in norepinephrine and a decrease in the firing rate of locus coeruleus (LC) neurones: this decrease is reversed by piperoxane, an alpha 2 antagonist.
Gene_expression (produce) of monoamine oxidase type A in brain associated with antagonist, locus ceruleus and monoamine
4) Confidence 0.58 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990957 Disease Relevance 0 Pain Relevance 0.31
Effects of monoamine oxidase inhibiting agents CDP-diacylglycerol formation and PI synthesis
Gene_expression (synthesis) of monoamine oxidase associated with monoamine
5) Confidence 0.52 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.56
The content of DA in blood and blood plasma, the characteristics of GABA and the opiate receptors of the brain, the activity of DBH, COMT, MAO, the content of cAMP and cGMP in brain tissue, as well as the expression of the gene c-fos were studied.
Gene_expression (expression) of MAO in brain associated with gaba and opiate
6) Confidence 0.46 Published 1994 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 7969881 Disease Relevance 0.25 Pain Relevance 0.19
The tricyclic antidepressants protriptyline and desipramine, the norepinephrine uptake inhibitor nisoxetine, the monoamine oxidase inhibitor phenelzine, and the atypical antidepressants bupropion, mirtazapine, and venlafaxine all produced greater than 90% isoproterenol-appropriate responding.
Gene_expression (produced) of monoamine oxidase associated with antidepressant, norepinephrine uptake inhibitor, desipramine, tricyclic antidepressant and monoamine
7) Confidence 0.42 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130722 Disease Relevance 0 Pain Relevance 0.55
Such animals might show abnormal expressions of each type of monoamine receptor (dopamine, serotonin, and noradrenaline receptors, including the subtypes of each receptor class) or monoamine oxidase in certain region(s) of the CNS.
Gene_expression (expressions) of monoamine receptor associated with dopamine, noradrenaline, central nervous system, serotonin and monoamine
8) Confidence 0.36 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0 Pain Relevance 0.57
Such animals might show abnormal expressions of each type of monoamine receptor (dopamine, serotonin, and noradrenaline receptors, including the subtypes of each receptor class) or monoamine oxidase in certain region(s) of the CNS.
Gene_expression (expressions) of monoamine oxidase associated with dopamine, noradrenaline, central nervous system, serotonin and monoamine
9) Confidence 0.36 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0 Pain Relevance 0.58
To determine whether this effect is shared by antidepressants from different pharmacological classes, PDE4A expression was examined using immunoblot analyses following repeated treatment with the norepinephrine re-uptake inhibitor desipramine, the monoamine oxidase inhibitor phenelzine, the atypical antidepressant trazodone, and the serotonin reuptake inhibitor fluoxetine.
Spec (examined) Gene_expression (expression) of monoamine oxidase associated with desipramine, antidepressant, serotonin, fluoxetine and monoamine
10) Confidence 0.35 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10693959 Disease Relevance 0 Pain Relevance 0.78
This suggests that MAO is one of the isatin-binding sites in situ.
Gene_expression (one) of MAO
11) Confidence 0.32 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.21 Pain Relevance 0.09
No differences were found at the COMT and MAOA genes among the three groups investigated.
Neg (No) Gene_expression (found) of MAOA
12) Confidence 0.07 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 16930369 Disease Relevance 1.04 Pain Relevance 0.90
Calcium channel antagonists are contraindicated in patients with hypotension, heart failure, atrioventricular block, Parkinson's disease or depression (flunarizine), and in those taking beta-adrenoceptor antagonists and monoamine oxidase inhibitors (verapamil).
Gene_expression (antagonists) of monoamine oxidase in heart associated with pressure volume 2 under development, depression, cv general 2 under development, antagonist, calcium channel, disease, myocardial infarction and monoamine
13) Confidence 0.04 Published 2006 Journal Drugs Aging Section Abstract Doc Link 16872231 Disease Relevance 1.60 Pain Relevance 1.00
These genetic differences could be explained by various genes, the HTR1B, encoding the 5-HT(1) receptor subtype, MAOA gene that encodes the monoamino-oxidase, the main metabolic enzyme of this triptan, SLC6A4 (gene encoding the serotonin transporter) and DRD(2) (gene encoding the D(2) receptor), both involved in the pathogenesis of migraine.
Gene_expression (enzyme) of MAOA gene associated with migraine, triptan and serotonin
14) Confidence 0.01 Published 2007 Journal J Headache Pain Section Abstract Doc Link 17563839 Disease Relevance 0.27 Pain Relevance 0.42

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