INT27171

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Context Info
Confidence 0.73
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.32
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
neurons 2
striatum 1
brain 1
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 51 100.00 Very High Very High Very High
Dopamine 38 100.00 Very High Very High Very High
monoamine 25 100.00 Very High Very High Very High
Locus ceruleus 8 100.00 Very High Very High Very High
positron emission tomography 4 99.10 Very High Very High Very High
fluoxetine 21 98.48 Very High Very High Very High
Raphe 8 98.04 Very High Very High Very High
Potency 13 95.76 Very High Very High Very High
Neurotransmitter 7 94.64 High High
sSRI 30 77.76 Quite High
Disease Link Frequency Relevance Heat
Disease 340 85.68 High High
Syndrome 4 84.52 Quite High
Disease Progression 24 62.84 Quite High
Parkinson's Disease 20 60.20 Quite High
Genetic Predisposition To Disease 4 39.92 Quite Low
Anxiety Disorder 1 39.52 Quite Low
Affective Disorder 1 38.16 Quite Low
Aggression 1 34.88 Quite Low
Apoptosis 36 7.00 Low Low
Depression 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAO-A is localized to the noradrenergic neurons of the locus coeruleus while MAO-B is present in the serotonergic neurons of the raphe nuclei and in glial cells.
Localization (localized) of MAO in neurons associated with locus ceruleus and raphe
1) Confidence 0.73 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 0.66 Pain Relevance 0.34
MAO-A is located primarily in peripheral organs where it contributes ?
Localization (located) of MAO
2) Confidence 0.73 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 0.72 Pain Relevance 0.40
MAO-A is localized to the noradrenergic neurons of the locus coeruleus while MAO-B is present in the serotonergic neurons of the raphe nuclei and in glial cells.
Localization (localized) of MAO in neurons associated with locus ceruleus and raphe
3) Confidence 0.73 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 0.60 Pain Relevance 0.34
In a small study of 3 healthy individuals administered rasagiline 1 mg per day for 10 days, positron emission tomography using 11C-L-deprenyl tracer showed complete blockade of MAO-B binding sites by rasagiline.31
Localization (blockade) of MAO associated with positron emission tomography
4) Confidence 0.73 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 0.07 Pain Relevance 0.13
Effect of long-term treatment with selective monoamine oxidase A and B inhibitors on dopamine release from rat striatum in vivo.
Localization (release) of monoamine oxidase in striatum associated with dopamine and monoamine
5) Confidence 0.71 Published 1996 Journal J. Neurochem. Section Title Doc Link 8858937 Disease Relevance 0 Pain Relevance 0.47
Consequently, the levels of 5-hydroxyindoleacetic acid in brain reflect MAO activity and not serotonin release or utilization.
Localization (release) of MAO in brain associated with serotonin
6) Confidence 0.70 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2580723 Disease Relevance 0.28 Pain Relevance 0.53
Consequently, the therapeutic actions of fluoxetine may [also] involve an inhibition of such enzyme and in particular the form MAO-B, which would result in a greater amount of 5-HT available for release as indeed already reported [44].
Localization (release) of MAO associated with fluoxetine
7) Confidence 0.60 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.88

General Comments

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